The PYRIN connection: novel players in innate immunity and inflammation.

The PYRIN connection: novel players in innate immunity and inflammation.
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pyrin的联系:先天免疫和炎症的新手。

DOI:
10.1084/jem.20032234
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发表时间:
2004-09-06
影响因子:
15.3
通讯作者:
Reed, JC
Reed, JC
中科院分区:
医学1区
文献类型:
--
作者:
Stehlik, C;Reed, JC

文献摘要

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Periodic fever syndromes (PFSs) comprise a subset of the hereditary autoinflammatory disorders that are defined by recurrent self-resolving attacks of systemic inflammatory reactions in the absence of infection or autoimmunity. Recent advances have led to the discovery that members of a new family of genes, the PYRIN family, account for several hereditary PFSs. Here we discuss new insights into the function of PYRIN proteins and the molecular basis of PFSs.
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