N400 evidence of abnormal responses to speech in Alzheimer's disease
N400 evidence of abnormal responses to speech in Alzheimer's disease
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DOI：
10.1016/0013-4694(96)95049-x
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发表时间：
1996-09-01
期刊：
影响因子：
--
通讯作者：
Roth, WT
中科院分区：
文献类型：
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作者：
Ford, JM;Woodward, SH;Roth, WT
采用言语诱发的事件相关脑电位（ERP）N400成分研究了阿尔茨海默病（AD）患者的语义启动状态。讲话的节奏很自然，在最后一个字之前有1秒的沉默。在语义任务中，受试者注意句子的含义，以进行随后的记忆测试。在音素监测任务中，他们计算了以字母“p”开头的单词。通过比较年轻人和老年人来评估年龄的影响，通过比较老年人和AD受试者来评估疾病的影响。在健康的年轻人和老年人受试者中，N400大到语义未启动的单词，小到语义启动的单词。在AD受试者中，N400对启动词很大，反映了句子干启动最后一个词的失败，可能是语义知识的损伤。的N400启动效应并不小于在任何组中的音素比语义任务，这表明，语音的语义质量的处理，即使当受试者参加音素的质量。N400潜伏期随年龄增长而延迟，痴呆进一步延迟。
The status of semantic priming in Alzheimer's disease (AD) was examined using the speech elicited N400 component of the event-related brain potential (ERP). Speech was naturally paced, with 1 s of silence before the final word. In the semantic task, subjects attended to the meaning of the sentences for a subsequent memory test. In the phonemic monitoring task, they counted the words beginning with the letter 'p'. The effects of age were assessed by comparing young and elderly, and the effects of disease by comparing elderly and AD subjects. In healthy young and elderly subjects, N400s were large to semantically unprimed words and small to semantically primed words. In AD subjects, N400s were large to primed words, reflecting a failure of the sentence stem to prime the final word, and probably an impairment in semantic knowledge. The N400 priming effect was not smaller during the phonemic than semantic task in any group, suggesting that the semantic qualities of speech are processed even when subjects are attending to phonemic qualities. N400 latency was delayed with age and further delayed with dementia.