Synergistic inactivation of plasma alpha 1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane.
Synergistic inactivation of plasma alpha 1-proteinase inhibitor by aldehydes of cigarette smoke with styrene oxide and 1,2-dichloroethane.
复制标题
香烟烟雾中的醛类与氧化苯乙烯和 1,2-二氯乙烷协同灭活血浆 α1-蛋白酶抑制剂。
DOI：
10.1007/bf01055520
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发表时间：
1988
影响因子：
4
通讯作者：
Barton,BK
中科院分区：
文献类型：
--
作者：
Ansari,GA;Gan,JC;Barton,BK
本实验室以前的研究表明，香烟烟雾中的醛类物质和工业化学品均可使α 1蛋白酶抑制剂（α1-PI）失活。研究表明，氧化苯乙烯或1，2-二氯乙烷与丙烯醛或乙醛混合时，α1-PI具有协同灭活作用，反之亦然。这些数据表明，在工业中暴露于化学品的吸烟者可能更容易发生肺气肿，这是由于化学品和香烟烟雾成分协同灭活α1-PI。
Previous studies from this laboratory have shown that α1proteinase inhibitor (α1-PI) can be inactivated by aldehydes found in the cigarette smoke as well as by industrial chemicals. Studies presented here demonstrate the synergistic inactivation of α1-PI by styrene oxide or 1,2-dichloroethane when mixed with acrolein or pyruvic aldehyde and vice-versa. The data suggest that smokers exposed to chemicals in industry may be more prone to lung emphysema due to synergistic inactivation of α1-PI by chemicals and cigarette smoke components.