Congenital Zika Syndrome: Prevalence of low birth weight and associated factors. Bahia, 2015-2017
Congenital Zika Syndrome: Prevalence of low birth weight and associated factors. Bahia, 2015-2017
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DOI：
10.1016/j.ijid.2019.02.040
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发表时间：
2019-05-01
影响因子：
8.4
通讯作者：
Teixeira, Maria Gloria
中科院分区：
文献类型：
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作者：
Carvalho-Sauer, Rita;Nascimento Costa, Maria da Conceicao;Teixeira, Maria Gloria
目的：先天性寨卡综合征（CZS）的临床表现尚不完全清楚，例如其对出生体重的影响。本研究估计了CZS儿童低出生体重（LBW）的患病率，并确定了相关factors.Methods：横断面研究涉及393名儿童CZS生活在巴西的巴伊亚，在2015-2017年。官方信息系统是数据来源。结果：CZS患儿LBW患病率为37.2%。不包括早产，这一比例为29.9%。早产儿和足月/足月出生儿童的患病率分别为81.0%和28.0%。其中女婴的比例较高（53.2%），剖宫产分娩的比例较高（51.4%）。大多数母亲是单身/分居的（62.1%），受教育程度低（70.0%）。在根据分娩类型调整的模型中，早产儿出现LBW的机会是足月/足月分娩的10.8倍。然而，置信区间非常宽。调整妊娠时间，剖宫产分娩的儿童出现LBW的概率比阴道分娩的高1.63（OR = 1.63; CI 95%1.01，2.63）。结论：无论是早产还是足月/足月活产，CZS儿童的LBW患病率都非常高。这可能会增加他们的死亡风险。已知LBW与早产和剖腹产的相关性，但在患有CZS的儿童中，尚不清楚这是否与寨卡病毒引起的胎儿感染引起的病理状况有关。(C)2019作者由爱思唯尔有限公司代表国际传染病学会出版。
Objective: The clinical manifestations of Congenital Zika Syndrome (CZS) are not fully known, for example its effect on birth weight. This study estimated the prevalence of low birth weight (LBW) among children with CZS, and identified associated factors.Methods: Cross-sectional study involving 393 children with CZS living in Bahia, Brazil, in 2015-2017. Official Information Systems were the data sources. We calculated LBW prevalence and applied Logistic Regression to assess associated factors.Results: Prevalence of LBW among children with CZS was 37.2%. Excluding pre-term births the proportion was 29.9%. This prevalence was 81.0% and 28.0% among children born pre-term and term/post term, respectively. There was a higher proportion (53.2%) in female children, and in those delivered by cesarean section (51.4%). Most mothers were single/separated (62.1%) and had a low level of schooling (70.0%). In the model adjusted for type of delivery, preterm births presented a 10.8 times greater chance of presenting LBW than term/post-term ones. However, the Confidence Interval was very wide. Adjusting for gestation duration, children born by cesarean section had a 1.63 higher probability of presenting LBW than those born by vaginal delivery (OR = 1,63; CI95% 1.01, 2.63).Conclusions: The prevalence of LBW among children with CZS was very elevated, both preterm and term/post-term live births. This can contribute to increasing their risk for morbimortality. The association of LBW with prematurity and cesarean deliveries is known, but in children with CZS, it has not been clarified whether or not this is related to pathological conditions caused by fetal infection by the Zika virus. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.