Both high expression of nucleophosmin/B23 and CRM1 predicts poorer prognosis in human gastric cancer
Both high expression of nucleophosmin/B23 and CRM1 predicts poorer prognosis in human gastric cancer
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DOI：
10.1111/apm.12604
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发表时间：
2016-10
期刊：
影响因子：
2.8
通讯作者：
F. Zhou;Ercheng Chen;D. You;Yipeng Song;Zhenni Sun;L. Yue
中科院分区：
文献类型：
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作者：
F. Zhou;Ercheng Chen;D. You;Yipeng Song;Zhenni Sun;L. Yue
核磷蛋白/B23和CRM 1是胃癌发生发展的重要分子标志物。然而，两者之间的联系仍不清楚。本研究探讨B23和CRM 1在胃癌中的表达及其相关性。应用免疫组化法检测131例胃癌患者胃癌及癌旁组织中B23和CRM 1的表达。B23和CRM 1在胃癌组织中的阳性表达率明显高于ANCT。B23和CRM 1的高表达率在肿瘤分期越晚、有远处转移的患者中越高（均P < 0.05）。只有CRM 1的高表达与Her 2阳性状态相关（p = 0.01）。胃癌组织中B23表达与CRM 1表达呈正相关（p = 0.038）。单因素分析显示，TNM分期（p = 0.0001）、转移（p = 0.027）、B23（p = 0.0111）和CRM 1表达（p = 0.0019）是影响总生存率的重要危险因素。胃癌患者B23和CRM 1的高表达均提示预后不良，两者共表达（p = 0.043）甚至更差。考克斯多因素分析显示，B23（p = 0.0231）和CRM 1（p = 0.0048）阳性表达均为独立的预后因素，与生存率呈负相关。我们揭示了B23或CRM 1在GC中的共表达。B23和CRM 1的表达水平与胃癌的不良预后密切相关，B23和CRM 1均为胃癌的独立危险因素。
Nucleophosmin/B23 and CRM1 are molecular markers which play an important role in tumorigenesis and tumor progression in gastric cancer (GC). However, the association between the two remains unclear. This study evaluated the expression and the correlation of B23 and CRM1 in GC. B23 and CRM1 expression in GC and adjacent noncancerous tissues (ANCT) of gastrectomy specimens from 131 GC patients was measured by immunohistochemistry. Positive expression rates of B23 and CRM1 were significantly higher in GC tissues than in ANCT. The high expression rates of B23 and CRM1 were significantly higher in patients with more advanced tumor stages and distant metastasis (all p < 0.05). Only high expression of CRM1was correlated with positive Her2 status (p = 0.01). B23 expression was positively correlated with CRM1expression in GC tissues (p = 0.038). Univariate analysis showed that TNM stage (p = 0.0001), metastasis (p = 0.027), B23 (p = 0.0111), and CRM1 expression (p = 0.0019) were significant risk factors affecting overall survival. Both high expression of B23 and CRM1 in GC patients suggests poor prognosis, co‐expression of the two (p = 0.043) even worse. Cox multivariate analysis showed that positive B23 (p = 0.0231) and CRM1 (p = 0.0048) expression were both independent prognostic factors that negatively correlated with survival. We revealed the co‐expression of B23 or CRM1 in GC. The expression levels of B23 or CRM1 were closely related to poor prognosis in GC, and both B23 or CRM1 were independent risk factor.