Stria Ultrastructure and Vessel Transport in Acoustic Trauma
Stria Ultrastructure and Vessel Transport in Acoustic Trauma
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声损伤中的纹状体超微结构和血管运输
DOI：
10.1177/000348947408300413
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发表时间：
1974
期刊：
影响因子：
--
通讯作者：
K. E. Lauhala
中科院分区：
文献类型：
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作者：
A. Duvall;W. D. Ward;K. E. Lauhala
110只龙猫暴露在700-2800赫兹123分贝的噪音中15分钟。耳蜗外侧壁超微结构病理表现一致。暴露后1小时首次观察到血管纹明显损伤，24小时达到峰值，28天几乎完全恢复。螺旋日珥损伤是永久性的。病理表现为纹增宽，中间细胞暂时消失，内膜系统改变，血管运输异常。辣根过氧化物酶（HRP）被用作从血管运输的指标。当纹状血管超微结构异常最大时，纹状血管的运输缺失；然而，在其他暴露后时间，在献祭前30秒静脉注射HRP的动物中，观察到HRP从纹血管中异常快速地流出。另一方面，在献祭前一分钟注射的动物没有观察到渗漏。提出了解释这种传输二分法的理论。
One hundred and ten chinchillas were exposed to a 700–2800 Hz noise at 123 dB for 15 minutes. A consistent pattern of ultrastructural pathology within the lateral cochlear wall was found. Significant damage to the stria vascularis was first observed one hour postexposure, reached a peak at 24 hours, and had recovered almost completely by 28 days. Spiral prominence damage was permanent. The pathology included stria widening, temporary disappearance of intermediate cells, alterations of the internal membrane system and abnormal vessel transport. Horseradish peroxidase (HRP) was employed as an indicator of transport from vessels. Transport from the stria vessels was absent when stria ultrastructural abnormality was at a maximum; at other postexposure times, however, abnormally rapid exodus of HRP from the vessels of the stria was observed in animals who had received intravenous injections of HRP 30 seconds prior to sacrifice. On the other hand, no leakage was observed in the animals injected one minute before sacrifice. Theories to explain this transport dichotomy are proposed.