Viral gene products actively promote latent infection by epigenetic silencing mechanisms.
Viral gene products actively promote latent infection by epigenetic silencing mechanisms.
复制标题
病毒基因产物通过表观遗传沉默机制积极促进潜伏感染。
DOI：
10.1016/j.coviro.2017.03.010
复制
发表时间：
2017-04
影响因子：
5.9
通讯作者：
Lee J
中科院分区：
文献类型：
--
作者：
Knipe DM;Raja P;Lee J
Many viruses undergo an acute infection in the host organism and then are cleared by the ensuing host immune response, but other viruses establish a persistent infection involving a latent infection or a chronic infection. Latent infection by the herpesviruses or human immunodeficiency virus involves epigenetic silencing of the DNA genome or proviral genome, respectively. Latent infection was previously thought to be a default pathway resulting from infection of a nonpermissive cell, but recent studies have shown that viral gene products can promote epigenetic silencing and latent infection. This review will summarize the viral gene products that have been shown to promote epigenetic silencing of their genomes and the potential for therapeutics to target these viral gene products and disrupt or lock in latent infection.
