ANTISPERM ANTIBODIES IN SEMINAL PLASMA OF SPINAL CORD-INJURED MEN
ANTISPERM ANTIBODIES IN SEMINAL PLASMA OF SPINAL CORD-INJURED MEN
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DOI：
10.1016/0090-4295(92)90298-b
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发表时间：
1992-03-01
期刊：
影响因子：
2.1
通讯作者：
STAAS, WE
中科院分区：
文献类型：
--
作者：
HIRSCH, IH;SEDOR, J;STAAS, WE
通过辅助射精技术治疗脊髓损伤男性的生殖康复问题的核心是对精液质量缺陷的一致观察。 大多数研究报道了弱精子症，尽管在大多数接受这些程序的男性中存在正常的精子浓度。 到目前为止，很少有人注意到精子自身免疫的发生率和相关性。 在9例脊髓损伤的无射精男性中，进行了电射精。 在7名男性中获得顺行射精并进行分析。 平均精子顺行浓度为74.4 +/- 113 x 10（6）/mL，平均活动精子浓度为28.6 +/- 54.0 x 10（6）/mL。 7名患者中有5名的精浆中酶联免疫吸附试验（ELISA）确定的抗精子抗体反应呈阳性。 由于免疫因素在神经源性不育男性中的发病率不成比例地高，精子自身免疫应被认为是导致其精液功能障碍的重要原因之一。
Central to the problem of reproductive rehabilitation of spinal cord-injured men treated by assisted ejaculatory techniques is the consistent observation of deficient semen quality. Most studies have reported asthenospermia despite the presence of normal sperm concentration in most men undergoing these procedures. To date little attention has been given to the incidence and relevance of sperm autoimmunity in this group. In 9 anejaculatory spinal cord-injured men, electroejaculation was performed. Antegrade ejaculates were obtained in 7 men and analyzed. Mean sperm antegrade concentration was 74.4 +/- 113 x 10(6)/mL with a mean motile sperm concentration of 28.6 +/- 54.0 x 10(6)/mL. Enzyme-linked immunosorbent assay (ELISA)-determined antisperm antibody response was positive in the seminal plasma of 5 of 7 patients. Because of the disproportionately high incidence of an immunologic factor in men with neurogenic infertility, sperm autoimmunity should be considered among the important causes underlying their seminal dysfunction.