Association of endothelin-converting enzyme-1b C-338A polymorphism with gastric cancer risk: A case-control study
Association of endothelin-converting enzyme-1b C-338A polymorphism with gastric cancer risk: A case-control study
复制标题
内皮素转换酶-1b C-338A 多态性与胃癌风险的关联：病例对照研究
DOI：
10.1016/j.ejca.2007.09.013
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发表时间：
2008-06-01
影响因子：
8.4
通讯作者：
Wang, Bin
中科院分区：
文献类型：
--
作者：
Gu, Haijuan;Yang, Li;Wang, Bin
To investigate the association between endothelin-converting enzyme-1b (ECE-1b) C-338A polymorphism and gastric cancer risk, we conducted a hospital-based case-control study of 256 gastric cancer cases and 256 controls matched on age and gender. The genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism. We found that the genotype frequencies were significantly different (P = 0.005) between cases and controls. Compared with the wild genotype CC, the variant genotypes (CA + AA) were associated with a 64% increased risk of gastric cancer [adjusted odds ratio (OR) = 1.64, 95% confidence interval (CI) 1.15-2.33]. Further stratification analyses indicated that the increased risk was especially noteworthy in older subjects (age >= 58) (adjusted OR=1.91, 95% CI 1.18-3.09), women (adjusted OR= 2.30, 95% CI 1.11-4.79) and non-smokers (adjusted OR = 1.79, 95% CI 1.19-2.67). Our results suggest that the ECE-1b C-338A polymorphism may be associated with increased risk of gastric cancer. (C) 2007 Elsevier Ltd. All rights reserved.
