The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water
The relationships between arsenic methylation and both skin lesions and hypertension caused by chronic exposure to arsenic in drinking water
复制标题
砷甲基化与慢性饮用水砷暴露引起的皮肤损伤和高血压的关系
DOI：
10.1016/j.etap.2017.05.009
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发表时间：
2017-07-01
影响因子：
4.3
通讯作者：
Wu, Kegong
中科院分区：
文献类型：
--
作者：
Wei, Binggan;Yu, Jiangping;Wu, Kegong
砷暴露，砷甲基化，皮肤病变和高血压的患病率之间的关联进行了调查。结果表明，与高血压组和无高血压皮肤损害组相比，高血压皮肤损害组和高血压皮肤损害组尿中无机砷、甲基胂酸、二甲基胂酸和甲基胂酸含量较高，二次砷甲基化指数较低。引起H的水中砷含量可能低于引起HS和S的水中砷含量。此外，比值比表明，较高的尿中iAs和MMA浓度、%iAs、%MMA和PMI仅升高高血压和皮肤病变的患病率，以及高血压和皮肤病变的患病率。然而，较高的%DMA和SMI，以及较低的%MMA增加了高血压和皮肤病变的患病率相比，只有皮肤病变。可见皮肤病变者高血压患病率较高。高血压受试者皮肤病变的患病率可能更高。较低的%DMA和SMI，较高的%iAs、%MMA和PMI仅增加高血压和皮肤病变的患病率，以及高血压和皮肤病变的患病率。此外，iAs和MMA可能具有更高的毒性，并导致高血压和皮肤病变，而不是仅导致高血压。
The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S. In addition, the odds ratios suggest that higher urinary concentrations of iAs and MMA, %iAs, %MMA and PMI elevate the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. However, higher%DMA and SMI, and lower%MMA increase the prevalence of both hypertension and skin lesions compared to that of only skin lesions. It can be concluded that skin lesions subjects have higher prevalence of hypertension. Hypertension subjects may have higher prevalence of skin lesions. Lower%DMA and SMI, higher%iAs, %MMA and PMI enhance the prevalence of only hypertension and skin lesions, and both hypertension and skin lesions. Moreover, iAs and MMA may have higher toxicity and lead to both hypertension and skin lesions than to only hypertension.