Serum concentrations of fatty acids and colorectal adenoma risk: a case-control study in Japan.
Serum concentrations of fatty acids and colorectal adenoma risk: a case-control study in Japan.
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2008
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通讯作者：
Reza Ghadimi;K. Kuriki;S. Tsuge;Emiru Takeda;N. Imaeda;Sadao Suzuki;Asuka Sawai;K. Takekuma;A. Hosono;Y. Tokudome;C. Goto;Imaneh Esfandiary;H. Nomura;S. Tokudome
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作者：
Reza Ghadimi;K. Kuriki;S. Tsuge;Emiru Takeda;N. Imaeda;Sadao Suzuki;Asuka Sawai;K. Takekuma;A. Hosono;Y. Tokudome;C. Goto;Imaneh Esfandiary;H. Nomura;S. Tokudome
背景n-3脂肪酸(FAs)与结直肠癌发病风险的流行病学研究结果不一致，与结直肠癌前体腺瘤(CRA)的关系尚未得到详细评估。在此，我们重点研究了日本人群中血清FAs与CRA之间的可能联系。方法对日本名古屋地区的203例无症状CRA患者(男148例，女55例)和179例健康对照(男67例，女112例)进行了病例对照研究。使用生活方式问卷获得基线信息，并用气相色谱测定血清FA水平。结果在女性中，二十碳五烯酸(EPA)与CRA无显著负相关。此外，n-3高不饱和脂肪酸(HUFAs)的主要成分二十二碳六烯酸(DHA)的浓度在男女病例中都明显较低。此外，血清总FAs、饱和FAs(SFAs)和单不饱和FAs(MUFAs)浓度与CRA风险有很强的正相关关系。相比之下，花生四烯酸(AA)和DHA呈负相关，风险分别降低66%和59%。SFAs/n-3PUFAs和SFAs/n-3HUFAs与CRA风险呈显著正相关，与n-6PUFAs/n-3PUFAs无明显相关性。结论SFA和MUFA对CRA风险有促进作用，DHA对CRA风险有保护作用。然而，需要进一步的研究来调查观察到的与公认的AA级联在致癌中的作用的差异。
BACKGROUND Epidemiologic studies of n-3 fatty acids (FAs) and risk of colorectal cancer have generated inconsistent results, and relations with precursor colorectal adenomas (CRA) have not been evaluated in detail. We here focused on possible associations of serum FAs with CRA in the Japanese population. METHODS We conducted a case-control study of 203 asymptomatic CRA cases (148 men, 55 women) and 179 healthy controls (67 men, 112 women) during 1997-2003 in Nagoya, Japan. Baseline information was obtained using a lifestyle questionnaire and serum FA levels were measured by gas chromatography. RESULTS A non-significant inverse association with CRA was observed for eicosapentaenoic acid (EPA) among women. Moreover, the concentrations of docosahexaenoeic acid (DHA), a major component of n-3 highly-unsaturated FAs (HUFAs), were significantly lower in cases in both sexes. In addition, serum concentrations of total FAs, saturated FAs (SFAs) and mono-unsaturated FAs (MUFAs) had strong positive links with CRA risk. In contrast, arachidonic acid (AA) and DHA were inversely related, with 66% and 59% risk reduction, respectively. Ratios of SFAs/n-3 PUFAs and SFAs/n-3 HUFAs exhibited significant positive relations with CRA risk but there was no clear link with n-6 PUFAs/n-3 PUFAs. CONCLUSIONS Our findings suggest a promoting influence of SFAs and MUFAs along with a protective effect of DHA on CRA risk. However, further research is needed to investigate the observed discrepancy with the generally accepted roles of the AA cascade in carcinogenesis.