Self-Reported Head Injury and Risk of Late-Life Impairment and AD Pathology in an AD Center Cohort
Self-Reported Head Injury and Risk of Late-Life Impairment and AD Pathology in an AD Center Cohort
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DOI：
10.1159/000355478
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发表时间：
2014-01-01
影响因子：
2.4
通讯作者：
Kryscio, Richard J.
中科院分区：
文献类型：
--
作者：
Abner, Erin L.;Nelson, Peter T.;Kryscio, Richard J.
目的：评估自报脑损伤与认知功能障碍、痴呆、死亡率和阿尔茨海默病（AD）型病理改变之间的关系。研究方法：对参加一项关于衰老和认知的纵向研究（n = 649）的参与者的临床和神经病理学数据进行分析，以评估自我报告的头部损伤的慢性影响。结果如下：自我报告的头部损伤对临床状态的影响取决于评估时的年龄：对于年龄增加1岁的参与者，有头部损伤史的参与者在下次访视时转变为临床轻度认知障碍（MCI）的OR为1.21，从MCI转变为痴呆的OR为1.34。与年龄无关，头部损伤增加了死亡率（OR = 1.54）。此外，它增加了男性（OR = 1.47）而不是女性（OR = 1.18）的AD病理诊断的几率。头部受伤的男性在新皮层和内嗅皮层中的平均淀粉样斑块计数高于没有受伤的男性。结论：自我报告的头部损伤与发病较早、认知障碍和痴呆风险增加、死亡风险增加和AD型病理改变相关。(C)2013 S. Karger AG，
Aims: To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes. Methods: Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. Results: The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. Conclusions: Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes. (C) 2013 S. Karger AG,