Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion.
Tumor and stromal-based contributions to head and neck squamous cell carcinoma invasion.
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DOI：
10.3390/cancers7010382
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发表时间：
2015-02-27
期刊：
影响因子：
5.2
通讯作者：
Weed SA
中科院分区：
文献类型：
--
作者：
Markwell SM;Weed SA
头颈部鳞状细胞癌（HNSCC）通常在晚期诊断为明显的局部区域和/或远端转移。转移性病变的流行与患者预后差直接相关，导致转移发展后患者死亡率高。转移性疾病的进展不仅需要癌细胞的改变，还需要周围基质细胞和肿瘤微环境的改变。在微环境中，来自周围细胞外基质的非细胞性贡献，以及各种浸润性免疫细胞、肿瘤相关成纤维细胞和内皮细胞的贡献，促进了肿瘤细胞从原发部位向身体其他部位的扩散。到目前为止，大多数通过治疗干预限制转移性扩散的尝试都未能在临床试验中显示患者受益。本综述的目的是强调HNSCC肿瘤微环境中促进侵袭的相互作用的复杂性，重点关注肿瘤和基质细胞的作用，以帮助未来的治疗开发和患者治疗。
Head and neck squamous cell carcinoma (HNSCC) is typically diagnosed at advanced stages with evident loco-regional and/or distal metastases. The prevalence of metastatic lesions directly correlates with poor patient outcome, resulting in high patient mortality rates following metastatic development. The progression to metastatic disease requires changes not only in the carcinoma cells, but also in the surrounding stromal cells and tumor microenvironment. Within the microenvironment, acellular contributions from the surrounding extracellular matrix, along with contributions from various infiltrating immune cells, tumor associated fibroblasts, and endothelial cells facilitate the spread of tumor cells from the primary site to the rest of the body. Thus far, most attempts to limit metastatic spread through therapeutic intervention have failed to show patient benefit in clinic trails. The goal of this review is highlight the complexity of invasion-promoting interactions in the HNSCC tumor microenvironment, focusing on contributions from tumor and stromal cells in order to assist future therapeutic development and patient treatment.
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影响因子：
4.8
作者：
Chang, Kai-Ping;Kao, Huang-Kai;Yu, Jau-Song
通讯作者：
Yu, Jau-Song
DOI：
10.4161/cc.21884
发表时间：
2012-10-01
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Capparelli C;Chiavarina B;Whitaker-Menezes D;Pestell TG;Pestell RG;Hulit J;Andò S;Howell A;Martinez-Outschoorn UE;Sotgia F;Lisanti MP
通讯作者：
Lisanti MP
影响因子：
4.3
作者：
Basu, Devraj;Montone, Kathleen T.;Herlyn, Meenhard
通讯作者：
Herlyn, Meenhard
影响因子：
4.8
作者：
Abram, CL;Seals, DF;Courtneidge, SA
通讯作者：
Courtneidge, SA
影响因子：
3.7
作者：
Bowden, ET;Onikoyi, E;Mueller, SC
通讯作者：
Mueller, SC