Peabody Picture Vocabulary Test: Proxy for Verbal IQ in Genetic Studies of Autism Spectrum Disorder
Peabody Picture Vocabulary Test: Proxy for Verbal IQ in Genetic Studies of Autism Spectrum Disorder
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DOI：
10.1007/s10803-017-3030-7
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发表时间：
2017-04-01
影响因子：
3.9
通讯作者：
Bal, Vanessa Hus
中科院分区：
文献类型：
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作者：
Krasileva, Kate E.;Sanders, Stephan J.;Bal, Vanessa Hus
这项研究评估了在自闭症谱系障碍(ASD)的大规模研究中，作为言语智商(VIQ)替代指标的简短评估(皮博迪图画词汇测试-第四版；PPVT4)的有效性。在2420名ASD先证者样本中，PPVT4：IQ有很强的相关性。PPVT4得分平均比VIQ高5.46分；79%的儿童PPVT4得分在其VIQ的一个标准差(+/-15)范围内，90%的儿童在这两个指标上都被归类为能力高于或低于70。PPVT4和VIQ在从头突变状态下的分布高度相似。这些结果有力地支持了PPVT4在大规模ASD研究中作为VIQ的替代指标的实用性，特别是在遗传学研究中。
This study assessed the utility of a brief assessment (the Peabody Picture Vocabulary Test-4th Edition; PPVT4) as a proxy for verbal IQ (VIQ) in large-scale studies of autism spectrum disorder (ASD). In a sample of 2,420 proband with ASD, PPVT4:IQ correlations were strong. PPVT4 scores were, on average, 5.46 points higher than VIQ; 79% of children had PPVT4 scores within one standard deviation (+/-15) of their VIQ and 90% were similarly classified as having abilities above or below 70 on both measures. Distributions of PPVT4 and VIQ by de novo mutation status were highly similar. These results strongly support the utility of PPVT4 as a proxy for VIQ in large-scale ASD studies, particularly for genetic investigations.