Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults
Lack of Associations between Elevated Serum Uric Acid and Components of Metabolic Syndrome Such as Hypertension, Dyslipidemia, and T2DM in Overweight and Obese Chinese Adults
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DOI：
10.1155/2019/3175418
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发表时间：
2019-12-04
影响因子：
4.3
通讯作者：
Yang, Xi
中科院分区：
文献类型：
--
作者：
Li, Li;Song, Qifa;Yang, Xi
超重和肥胖人群高尿酸血症和代谢综合征的发生率较高。本研究旨在探讨 409 名 BMI > 24 kg/m(2) 的中国肥胖成年人（254 名女性和 155 名男性）的血清尿酸与代谢综合征相关危险因素之间的关系。根据性别特异性参考范围，233 名患者 (57%) 出现血清尿酸升高。总共选择了15个属性来评估血清尿酸升高与代谢综合征成分之间的关联，包括血清尿酸、总胆固醇、HDL-C、LDL-C、甘油三酯、收缩压、空腹血糖、糖化血红蛋白、HOMA-IR、丙氨酸氨基转移酶、肌酐、尿微量白蛋白、肌肉量、BMI和年龄。在分为 I 级、II 级和 III 级肥胖三组的参与者中，以及分为男性和女性组的参与者中，单变量相关分析发现负相关（P
The overweight and obese population experiences a higher occurrence of both hyperuricemia and metabolic syndrome. The present study was to explore the relationship between serum uric acid and metabolic syndrome-related risk factors among 409 obese Chinese adults (254 women and 155 men) with >24 kg/m(2) BMI. Based on sex-specific reference ranges, 233 (57%) patients showed elevated serum uric acid. A total of 15 attributes were selected to assess the associations between elevated serum uric acid and components of metabolic syndrome, including serum uric acid, total cholesterol, HDL-C, LDL-C, triglyceride, systolic blood pressure, fasting blood glucose, glycosylated hemoglobin, HOMA-IR, alanine aminotransferase, creatinine, urine microalbumin, muscle mass amount, BMI, and age. Among the participants stratified into three groups of grade I, grade II, and grade III obesity, as well as among the participants stratified into male and female groups, univariate correlation analysis identified a negative association (P