Immunomodulatory effect of beta-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer.
Immunomodulatory effect of beta-carotene on T lymphocyte subsets in patients with resected colonic polyps and cancer.
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β-胡萝卜素对结肠息肉和癌症切除患者 T 淋巴细胞亚群的免疫调节作用。
DOI：
10.1080/01635589709514566
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Mobarhan,S
中科院分区：
文献类型：
--
作者：
Kazi,N;Radvany,R;Oldham,T;Keshavarzian,A;Frommel,TO;Libertin,C;Mobarhan,S
许多研究结果表明，含有β -胡萝卜素的食物可以预防各种癌症的发生或发展。这种效应的一种可能机制是增强免疫反应。本研究的目的是确定β -胡萝卜素是否调节？结肠息肉或癌性病变患者的淋巴细胞亚群。既往患有腺瘤性结肠息肉（n = 18）或结肠癌（n = 19）的患者随机接受安慰剂或β -胡萝卜素（30 mg/天）治疗3个月。的百分比？使用流式细胞术测定随机分组前和三个月时采集的血液样本中的淋巴细胞亚群。？ 同时测定14例正常对照者的淋巴细胞亚群进行比较。最初，三组患者在白细胞总数、淋巴细胞百分比和各种淋巴细胞亚群方面没有差异，尽管癌症患者的CD4和白细胞介素- 2 （IL - 2）受体阳性（IL - 2R+）细胞的百分比低于息肉患者和对照组。在补充β -胡萝卜素后，IL - 2R+ ？淋巴细胞（12.7±3.0%至26.0±1.9%）和CD4+淋巴细胞（40.9±3.1%至45.6±3.2%）仅在肿瘤患者中可见。在接受安慰剂或β -胡萝卜素治疗的腺瘤性息肉患者中，这些百分比保持不变。我们的结论是β -胡萝卜素增加了IL - 2R+？淋巴细胞和CD4+淋巴细胞，这两种细胞反过来可能只在免疫系统已经有一些缺陷的癌症患者中产生IL - 2。激活？淋巴细胞可能通过细胞因子的产生介导对癌细胞的细胞毒性反应。
Results from a number of studies suggest that β‐carotene‐containing foods prevent the initiation or progression of various cancers. One possible mechanism for this effect could be enhancement of the immune response. The aim of this study was to determine whether β‐carotene modulates ? lymphocyte subsets in patients affected with colonic polyps or cancerous lesions. Patients with previous adenomatous colonic polyps (n = 18) or colon cancers (n = 19) were randomized to receive placebo or β‐carotene (30 mg/day) for three months. Percentages of ? lymphocyte subsets were determined using flow cytometry in blood samples collected before randomization and at three months. ? lymphocyte subsets of 14 normal control subjects were also determined for comparison. Initially, there was no difference in total leukocyte counts, percentage of lymphocytes, and various subsets of lymphocytes among the three groups, although in cancer patients there was a lower percentage of CD4 and interleukin‐2 (IL‐2) receptor‐positive (IL‐2R+) cells than in patients with polyps and in controls. After supplementation with β‐carotene, a significant increase in IL‐2R+ ? lymphocytes (from 12.7 ±3.0% to 26.0 ±1.9%) and CD4+lymphocytes (from 40.9 ± 3.1% to 45.6 ± 3.2%) was seen only in the cancer patients. These percentages remained unchanged in patients with adenomatous polyps receiving placebo or β‐carotene. We concluded that β‐carotene increased the number of IL‐2R+? lymphocytes and CD4+lymphocytes, which in turn may produce IL‐2 only in patients with cancer who may already have some deficiency in their immune system. This increase in activated ? lymphocytes may mediate cytotoxic reactions to cancer cells via cytokine production.
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DOI：
10.1073/pnas.85.17.6503
发表时间：
1988
影响因子：
11.1
作者：
McGuire,KL;Yang,JA;Rothenberg,EV
通讯作者：
Rothenberg,EV
影响因子：
8.8
作者：
Wald, N J;Thompson, S G;Densem, J W;Boreham, J;Bailey, A
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DOI：
10.1093/ajcn/48.5.1277
发表时间：
1988
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Costantino,JP;Kuller,LH;Begg,L;Redmond,CK;Bates,MW
通讯作者：
Bates,MW
癌症患者血清白细胞介素2水平、可溶性白细胞介素2受体与T淋巴细胞亚群的相关性
影响因子：
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作者：
P. Lissoni;S. Barni;F. Rovelli;R. Rescaldani;V. Rizzo;A. Biondi;G. Tancini
通讯作者：
G. Tancini
神经性厌食症患者外周血造血干细胞发生率低
DOI：
--
发表时间：
1988
期刊：
影响因子：
--
作者：
K. Geissler;A. Kiss;W. Hinterberger;S. Wiesnagrotzki
通讯作者：
S. Wiesnagrotzki