ABSORPTION KINETICS OF ASPIRIN IN MAN FOLLOWING ORAL ADMINISTRATION OF AN AQUEOUS-SOLUTION
ABSORPTION KINETICS OF ASPIRIN IN MAN FOLLOWING ORAL ADMINISTRATION OF AN AQUEOUS-SOLUTION
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DOI：
10.1002/jps.2600610312
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发表时间：
1972-01-01
影响因子：
3.8
通讯作者：
RIEGELMAN, S
中科院分区：
文献类型：
--
作者：
ROWLAND, M;SHOLKOFF, SD;RIEGELMAN, S
The absorption of aspirin was studied in four male subjects following an oral solution of 650 mg. The absorption process appeared to follow first-order kinetics, with a half-life ranging from 4.5 to 16.0 min. between subjects. Comparison of the area under the aspirin plasma concentration-time curve following intravenous and oral routes indicated that only 68% of the dose reached the peripheral circulation intact. A two-compartment model for both aspirin and its metabolite, salicylic acid, involving a constant fractional hydrolysis of aspirin during absorption, satisfactorily described both the aspirin and resultant salicylic acid plasma data. Methods used to calculate aspirin absorption kinetics are discussed.
