Racial disparities in prostate cancer: a molecular perspective.
Racial disparities in prostate cancer: a molecular perspective.
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前列腺癌的种族差异：分子视角。
DOI：
10.2741/4515
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发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Singh AP
中科院分区：
文献类型：
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作者：
Bhardwaj A;Srivastava SK;Khan MA;Prajapati VK;Singh S;Carter JE;Singh AP
与欧洲裔美国人相比，非洲裔美国人的前列腺癌发病率和死亡率明显更高。尽管有这些认识，但人们对这种普遍存在的种族差距背后的确切原因仍然知之甚少。尽管社会经济因素可以在一定程度上解释这种差异，但现在越来越多的人意识到，这种差异是有分子基础的。事实上，在来自不同种族背景的患者的恶性前列腺组织中，已经报道了几种差异，包括遗传多态、基因突变、表观遗传修饰、miRNAs改变等。在这里，我们试图通过收集这些相关因素的可用信息，并讨论它们在不成比例的发病率和临床结果中的潜在意义，来提供前列腺癌种族差异的分子视角。
Prostate cancer incidence and mortality rates are remarkably higher in African-American men as compared to their European-Americans counterparts. Despite these recognitions, precise causes underlying such prevalent racial disparities remain poorly understood. Although socioeconomic factors could account for such differences up to a certain extent, it is now being increasingly realized that such disparity has a molecular basis. Indeed, several differences, including genetic polymorphism, gene mutations, epigenetic modifications, miRNAs alterations, etc., have been reported in malignant prostate tissues from patients of diverse racial backgrounds. Here, we attempt to provide a molecular perspective on prostate cancer racial disparities by gathering available information on these associated factors and discussing their potential significance in disproportionate incidence and clinical outcomes.