Are fluoride releasing dental materials clinically effective on caries control?
Are fluoride releasing dental materials clinically effective on caries control?
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DOI：
10.1016/j.dental.2015.12.002
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发表时间：
2016-03-01
期刊：
影响因子：
5
通讯作者：
Andalo Tenuta, Livia Maria
中科院分区：
文献类型：
--
作者：
Cury, Jaime Aparecido;de Oliveira, Branca Heloisa;Andalo Tenuta, Livia Maria
目标。(1)描述龋损的发生和氟在控制疾病进展中的作用；(2)评价使用含氟窝沟封闭剂、粘结剂和修复材料与非氟释放材料相比是否降低儿童和成人的龋患率；(3)讨论这些材料的防龋性在体外和现场的评价。检索Cochrane系统综述数据库和通过Pubmed检索Medline。龋病是一种依赖生物膜和糖的疾病，因此它会逐渐破坏任何牙齿表面的矿物质结构--完整的、封闭的或修复的--那里的生物膜仍在积累并经常暴露在糖中。从牙科材料中释放的氟化物对龋齿的作用机制与牙膏或其他氟化物载体中的氟化物相似。氟化物释放材料不能干扰邻近牙齿表面的生物膜的形成，也不能抑制牙齿生物膜的产酸。然而，释放的氟化物减缓了与牙科材料相邻的牙齿表面的龋损进展。这一效应已经在体外和原位研究中清楚地显示出来，但在随机临床试验中还没有显示出来。氟化物释放材料的防龋性还没有临床证据，而且，它可能被牙膏释放的氟化物所淹没。(C)2015年牙科材料学会。爱思唯尔有限公司出版。保留所有权利。
Objectives. (1) To describe caries lesions development and the role of fluoride in controlling disease progression; (2) to evaluate whether the use of fluoride-releasing pit and fissure sealants, bonding orthodontic agents and restorative materials, in comparison to a non fluoride releasing material, reduces caries incidence in children or adults, and (3) to discuss how the anti-caries properties of these materials have been evaluated in vitro and in situ.Methods. The search was performed on the Cochrane Database of Systematic Reviews and on Medline via Pubmed.Results. Caries is a biofilm-sugar dependent disease and as such it provokes progressive destruction of mineral structure of any dental surface - intact, sealed or restored - where biofilm remains accumulated and is regularly exposed to sugar. The mechanism of action of fluoride released from dental materials on caries is similar to that of fluoride found in dentifrices or other vehicles of fluoride delivery. Fluoride-releasing materials are unable to interfere with the formation of biofilm on dental surfaces adjacent to them or to inhibit acid production by dental biofilms. However, the fluoride released slows down the progression of caries lesions in tooth surfaces adjacent to dental materials. This effect has been clearly shown by in vitro and in situ studies but not in randomized clinical trials.Significance. The anti-caries effect of fluoride releasing materials is still not based on clinical evidence, and, in addition, it can be overwhelmed by fluoride delivered from dentifrices. (C) 2015 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.