Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
Polymorphisms in Toll-like receptor 4 and the systemic inflammatory response syndrome
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DOI：
10.1042/bst0310652
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发表时间：
2003-06-01
影响因子：
3.9
通讯作者：
Holloway, JW
中科院分区：
文献类型：
--
作者：
Child, NJA;Yang, IA;Holloway, JW
全身炎症反应综合征（SIRS）是发病和死亡的主要原因，并且被认为是由于炎症反应的过度放大。Toll样受体4（TLR 4）Asp-299 -> Gly多态性已被证明降低脂多糖反应性。我们研究了TLR 4多态性是否与SIRS的严重程度相关。在SIRS中发现次要等位基因与死亡率之间的趋势（优势比为4.3; P = 0.076），表明TLIR 4信号传导在SIRS的严重性中的作用。
The systemic inflammatory response syndrome (SIRS) is a major cause of morbidity and mortality, and is thought to be due to an over-amplification of an inflammatory response. The Toll-like receptor 4 (TLR4) Asp-299 --> Gly polymorphism has been shown to reduce lipopolysaccharide responsiveness. We examined whether this TLR4 polymorphism is associated with severity of SIRS. A trend was found between the minor allele and mortality in SIRS (odds ratio of 4.3; P = 0.076), suggesting a role for TLIR4 signalling in the severity of SIRS.