Pathogenesis of irradiation-induced cognitive dysfunction
Pathogenesis of irradiation-induced cognitive dysfunction
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DOI：
10.3109/02841869609083995
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发表时间：
1996-01-01
期刊：
影响因子：
3.1
通讯作者：
Abayomi, OK
中科院分区：
文献类型：
--
作者：
Abayomi, OK
神经认知功能障碍是颅脑照射的常见后遗症，在幼儿中尤其严重。这种疾病的潜在机制尚未被描述，本综述描述了海马体和解剖学相关皮层在记忆功能中的作用及其对缺血和缺氧损伤的显着易感性。根据对人类失忆症动物模型的研究和受辐射大脑的组织病理学发现，颅脑辐射的神经认知后遗症可以通过血管损伤介导，导致海马区缺血和缺氧。对这种损伤的部位和机制的认识可能会导致技术的发展，以最大限度地降低风险。
Neurocognitive dysfunction is a common sequela of cranial irradiation that is especially severe in young children. The underlying mechanisms of this disorder have not been described, The present review describes the role of the hippocampus and the anatomically related cortex in memory function and its marked susceptibility to ischemic and hypoxic injury. Based on studies of animal models of human amnesia and histopathological findings in the irradiated brain, the neurocognitive sequela of cranial irradiation can be seen to be mediated through vascular injury, resulting in ischemia and hypoxia in the hippocampal region, Recognition of the site and mechanisms of this injury may lead to the development of techniques to minimize the risks.