Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences.
Early adverse life events and resting state neural networks in patients with chronic abdominal pain: evidence for sex differences.
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DOI：
10.1097/psy.0000000000000089
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发表时间：
2014-07
影响因子：
3.3
通讯作者：
Mayer EA
中科院分区：
文献类型：
--
作者：
Gupta A;Kilpatrick L;Labus J;Tillisch K;Braun A;Hong JY;Ashe-McNalley C;Naliboff B;Mayer EA
早期不良生活（EAL）事件和性别已被确定为几种应激敏感性疾病（包括肠易激综合征（IBS））发展的易感因素。我们旨在确定IBS患者中与EALs相关的静息状态（RS）连接的疾病和性别差异。使用早期创伤量表评估18岁之前的EALs病史。使用RS功能磁共振成像识别168人（58名IBS， 28名女性；110名健康对照，72名女性）RS网络形式的内在脑振荡模式。偏最小二乘法是一种多变量分析技术，用于确定疾病和性别差异，以及六个已确定的RS网络中EALs和功能连接之间可能的相关性。观察到EALs和RS网络之间的关联。在男性和女性IBS患者中，EALs病史与显著性/执行控制网络连通性的改变有相似程度的关联（Bootstrap比值[BSR]=3.28-5.61; p= 0.046），男性IBS患者在小脑网络中表现出额外的EALs相关改变（BSR=3.92-6.79; p= 0.022）。这项横断面研究确定了肠易激综合征患者RS网络与EALs之间的相关性。这些结果表明，在18岁之前暴露于EALs可以在显着性/执行控制网络中塑造成年男性和女性患者的RS，这是一个与中枢性疼痛放大的病理生理学有关的大脑网络。
Early adverse life (EAL) events and sex have been identified as vulnerability factors for the development of several stress-sensitive disorders, including irritable bowel syndrome (IBS). We aimed to identify disease and sex-based differences in resting state (RS) connectivity associated with EALs in individuals with IBS. A history of EALs before age 18 was assessed using the early trauma inventory. RS functional magnetic resonance imaging was used to identify patterns of intrinsic brain oscillations in the form of RS networks in 168 people (58 IBS, 28 females; and 110 healthy controls, 72 females). Partial Least Squares, a multivariate analysis technique was used to identify disease and sex differences and possible correlations between EALs and functional connectivity in six identified RS networks. Associations between EALs and RS networks were observed. While a history of EALs was associated with altered connectivity in the salience/executive control network to a similar extent in male and female IBS patients (Bootstrap ratio [BSR]=3.28-5.61; p=.046), male IBS patients demonstrated additional EAL-related alterations in the cerebellar network (BSR=3.92-6.79; p=.022). This cross sectional study identified correlations between RS networks and EALs in individuals with IBS. These results suggest that exposure to EALs before age 18 can shape adult RS in both male and female patients in the salience/executive control network, a brain network that has been implicated in the pathophysiology of central pain amplification.