EFFECT OF DIETARY-FAT SELECTION ON PLASMA-CHOLESTEROL SYNTHESIS IN OLDER, MODERATELY HYPERCHOLESTEROLEMIC HUMANS
EFFECT OF DIETARY-FAT SELECTION ON PLASMA-CHOLESTEROL SYNTHESIS IN OLDER, MODERATELY HYPERCHOLESTEROLEMIC HUMANS
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DOI：
10.1161/01.atv.14.4.542
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发表时间：
1994-04-01
期刊：
影响因子：
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通讯作者：
NAMCHUK, GL
中科院分区：
文献类型：
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作者：
JONES, PJH;LICHTENSTEIN, AH;NAMCHUK, GL
为了研究控制血浆胆固醇水平的因素，在15名高胆固醇血症受试者（低密度脂蛋白[LDL]胆固醇> 130 mg . dL-1）在32天的时间内消耗（1）基线饮食（36%千卡脂肪：15%饱和脂肪、15%单不饱和脂肪和6%多不饱和脂肪; 180 mg胆固醇。1000 kcal-1）和符合国家胆固醇教育计划第2步标准（30% kcal脂肪，小于或等于7%饱和脂肪，80至85 mg胆固醇/Mcal）的饮食，其中三分之二的脂肪是（2）橄榄油，（3）玉米，或（4）菜籽油。在每个阶段结束时测定血浆总胆固醇、低密度脂蛋白、高密度脂蛋白胆固醇和甘油三酯水平。胆固醇部分合成速率（FSR）也被测量为相对于身体D2 O水平（1.2g D2 O）的氘（D）掺入血浆总胆固醇中。kg-1估计的身体水分）。绝对合成速率（ASR）被确定为FSR和快速周转胆固醇池大小的乘积。血浆总胆固醇和低密度脂蛋白胆固醇水平显著下降（P
To study factors controlling plasma cholesterol levels, the effect of dietary fat type on cholesterol synthesis was examined in 15 hypercholesterolemic subjects (low-density lipoprotein [LDL] cholesterol > 130 mg . dL-1) consuming over a period of 32 days (1) a baseline diet (36% kcal as fat: 15% saturated, 15% monounsaturated, and 6% polyunsaturated fat; 180 mg cholesterol . 1000 kcal-1) and diets meeting National Cholesterol Education Program step 2 criteria (30% kcal as fat, less-than-or-equal-to 7% saturated fat, 80 to 85 mg cholesterol/Mcal), where two thirds of the fat was either (2) olive, (3) corn, or (4) canola oil. Plasma total, LDL, and high-density lipoprotein (HDL) cholesterol and triglyceride levels were determined at the end of each period. Cholesterol fractional synthesis rate (FSR) was also measured as the deuterium (D) incorporation into plasma total cholesterol relative to body D2O level (1.2 g D2O . kg-1 estimated body water) over 24 hours. Absolute synthesis rates (ASRs) were determined as the product of FSR and rapid turnover cholesterol pool size. Plasma total and LDL cholesterol levels declined significantly (P