Histopathologic findings of retrieved specimens of vertebroplasty with polymethylmethacrylate cement - Case control study
Histopathologic findings of retrieved specimens of vertebroplasty with polymethylmethacrylate cement - Case control study
复制标题
DOI：
10.1097/01.brs.0000182226.56498.55
复制
发表时间：
2005-10-01
期刊：
影响因子：
3
通讯作者：
Lin, RM
中科院分区：
文献类型：
--
作者：
Huang, KY;Yan, JJ;Lin, RM
研究设计。病例对照研究。目的。旨在研究 2 个聚甲基丙烯酸甲酯 (PMMA) 水泥椎体成形术失败标本的组织病理学结果。背景数据摘要。使用 PMMA 水泥的椎体成形术通常用于治疗压缩性骨折、血管瘤和转移性癌症引起的衰弱性背痛。然而，人们对 PMMA 水泥未来不可预测的结果感到担忧。其组织病理学变化鲜有报道。方法。取回 2 个 PMMA 增强的骨折椎体和 3 个未增强的骨折椎体用于组织病理学研究。我们比较了两组之间骨坏死、异物反应、纤维化壁形成和新生血管形成的结果。在 PMMA 水泥的周围观察到骨坏死，其周围被纤维化组织包围。相反，在未增强的对照组中未发现纤维化壁形成。仅在 PMMA 增强病例中观察到异物反应，仅在对照病例中观察到新生血管形成。结论。 PMMA 水泥可能不像我们想象的那样具有生物惰性。因此，应进一步评估椎体成形术的长期安全性。
Study Design. Case control study.Objective. To investigate the histopathologic findings of 2 retrieved specimens from failed vertebroplasty with polymethylmethacrylate (PMMA) cement.Summary of Background Data. Vertebroplasty using PMMA cement has been commonly used to treat debilitating back pain from compression fracture, angiomas, and metastatic cancer. However, there was concern about the unpredictable future results with PMMA cement. The histopathologic changes were rarely reported.Methods. There were 2 PMMA augmented and 3 nonaugmented fractured vertebral bodies retrieved for histopathologic study. Between the 2 groups, we compared the findings of bone necrosis, foreign body reaction, fibrotic wall formation, and neovascularization.Results. Bone necrosis was noted in the periphery of PMMA cement, which was surrounded by fibrotic tissues. In contrast, no fibrotic wall formation could be found in the nonaugmented control group. Foreign body reaction was only noted in PMMA augmented cases, and neovascularization was only noted in the control cases.Conclusion. PMMA cement might not be as bioinert as we considered. Therefore, the long-term safety of vertebroplasty should be further evaluated.