CD24 and human carcinoma: tumor biological aspects
CD24 and human carcinoma: tumor biological aspects
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DOI：
10.1016/s0753-3322(05)80076-9
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发表时间：
2005-10-01
影响因子：
7.5
通讯作者：
Lim, SC
中科院分区：
文献类型：
--
作者：
Lim, SC
CD 24是一种粘蛋白样粘附分子，最近引起了人们的关注，并为我们对肿瘤生物学的理解提供了实质性的改进。在功能上，CD 24增强恶性细胞的转移潜能，因为它已被鉴定为P-选择素的配体，P-选择素是活化的内皮细胞和血小板上的粘附受体。此外，它已被描述为恶性肿瘤和患者预后的诊断分子标志物。本文从肿瘤生物学的角度对CD 24表达与肿瘤的实验和临床资料进行综述。基于这项研究，CD 24表达将被分析为各种人类癌症诊断的潜在重要参数。了解CD 24的功能和意义可能有助于临床医生为个体患者选择合适的治疗方法：例如，静脉注射CD 24特异性抗体治疗癌症。(c)2005年，Elsevier SAS。All rights reserved.
CD24 is a mucin-like adhesion molecule that has recently raised attention and lent substantial improvements for our understanding of tumor biology. Functionally, CD24 enhances the metastatic potential of malignant-cells, because it has been identified as a ligand of P-selectin, an adhesion receptor on activated endothelial cells and platelets. Moreover, it has been described as a diagnostic molecular marker of malignant tumor and for patient prognosis. This article reviews the experimental and clinical data on CD24 expression and carcinomas from the point of view of tumor biology. Based on the research, CD24 expression will be analyzed as a potentially significant parameter for a wide variety of human cancer diagnoses. Understanding the functions and implications CD24 might aid the clinician in the selection of an appropriate therapy for individual patients: for example, the intravenous administration of CD24-specific antibodies to treat cancers. (c) 2005 Elsevier SAS. All rights reserved.