From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
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DOI：
10.1016/j.antiviral.2013.08.015
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发表时间：
2013-10
影响因子：
7.6
通讯作者：
Peiris M
中科院分区：
文献类型：
--
作者：
Hilgenfeld R;Peiris M
我们回顾了2002-2003年严重急性呼吸综合征（SARS）的爆发和患者的抗病毒治疗。我们回顾了合理设计抗 SARS 疗法的努力。我们提供了冠状病毒蛋白所有可用 3 维结构的完整列表。我们讨论了新出现的中东呼吸综合征冠状病毒，并回顾了几种可用于治疗的抗病毒药物。我们批判性地讨论从非典中吸取了哪些教训，哪些尚未吸取。本文介绍了《Antiviral Research》上一系列特邀论文，纪念 2002 年底在中国南方出现的一种新型冠状病毒引起的严重急性呼吸系统综合症 (SARS) 爆发 10 周年。在那之前，冠状病毒尚未被认为是导致人类严重疾病的病原体，因此 SARS-CoV 的出现完全令人意外。过去十年的研究表明，不同蝙蝠物种和其他动物之间存在着多种冠状病毒，这表明高致病性冠状病毒进一步引入人类不仅是可能的，而且是不可避免的。最近出现的另一种导致人类严重疾病的冠状病毒——中东呼吸综合征（MERS），清楚地表明冠状病毒对人类健康构成重大威胁，迫切需要更多的研究来阐明其复制机制、识别潜在的药物靶点并制定有效的对策。在本系列中，冠状病毒复制和疾病许多不同方面的专家将对以下主题提供权威的最新评论： – SARS 的临床管理和感染控制； – 冠状病毒的储存宿主； – SARS-CoV 的受体识别和跨物种传播； – SARS-CoV 逃避先天免疫反应； – 单个冠状病毒蛋白的结构和功能； – 抗冠状病毒药物的发现和开发； – SARS 爆发的公共卫生遗产。每篇文章的摘要最后一行都将被标识为属于“从 SARS 到 MERS：高致病性人类冠状病毒的 10 年研究”系列。
We review the outbreak of severe acute respiratory syndrome (SARS) in 2002–2003 and antiviral treatment of patients. We review efforts towards the rational design of anti-SARS therapeutics. We present a comprehensive list of all available 3-dimensional structures of coronavirus proteins. We discuss the emerging MERS coronavirus and review the few antivirals available for treatment. We critically discuss which lessons have been learned from SARS and which are yet to be learned. This article introduces a series of invited papers in Antiviral Research marking the 10th anniversary of the outbreak of severe acute respiratory syndrome (SARS), caused by a novel coronavirus that emerged in southern China in late 2002. Until that time, coronaviruses had not been recognized as agents causing severe disease in humans, hence, the emergence of the SARS-CoV came as a complete surprise. Research during the past ten years has revealed the existence of a diverse pool of coronaviruses circulating among various bat species and other animals, suggesting that further introductions of highly pathogenic coronaviruses into the human population are not merely probable, but inevitable. The recent emergence of another coronavirus causing severe disease, Middle East respiratory syndrome (MERS), in humans, has made it clear that coronaviruses pose a major threat to human health, and that more research is urgently needed to elucidate their replication mechanisms, identify potential drug targets, and develop effective countermeasures. In this series, experts in many different aspects of coronavirus replication and disease will provide authoritative, up-to-date reviews of the following topics: – clinical management and infection control of SARS; – reservoir hosts of coronaviruses; – receptor recognition and cross-species transmission of SARS-CoV; – SARS-CoV evasion of innate immune responses; – structures and functions of individual coronaviral proteins; – anti-coronavirus drug discovery and development; and – the public health legacy of the SARS outbreak. Each article will be identified in the last line of its abstract as belonging to the series “From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.”
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影响因子：
11.4
作者：
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DOI：
10.1016/j.bbapap.2013.03.003
发表时间：
2013-06
影响因子：
3.2
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Hou, Ming-Hon
影响因子：
56.9
作者：
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3.8
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