Real versus imagined locomotion: A [18F]-FDG PET-fMRI comparison
Real versus imagined locomotion: A [18F]-FDG PET-fMRI comparison
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DOI：
10.1016/j.neuroimage.2009.12.060
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发表时间：
2010-05-01
期刊：
影响因子：
5.7
通讯作者：
Jahn, Klaus
中科院分区：
文献类型：
--
作者：
la Fougere, Christian;Zwergal, Andreas;Jahn, Klaus
大脑皮层，小脑和脑干的BOLD信号的变化已被确定与功能磁共振成像在人类行走的心理意象。在这项研究中，在真实的运动的全脑激活和失活模式进行了研究，[F-18]FDG-PET和BOLD信号的变化相比，在想象中的运动在同一主题使用功能磁共振成像。用[F-18]-FDG-PET对16名健康受试者在运动和休息时进行扫描。在运动范例中，受试者以恒定速度行走10分钟。然后静脉注射[F-18]-FDG，同时受试者继续行走另外10分钟。在真实的和想象的运动过程中，一个基本的运动网络，包括额叶皮层，小脑，桥中脑被盖，海马旁回，梭状回和枕回的激活，和多感觉前庭皮层（特别是上级颞回，顶下小叶）的失活。不同的是，在真实的运动中，初级运动皮层和体感皮层被激活，而在想象运动中，辅助运动皮层和基底神经节被激活。脑干运动中枢的激活在想象运动中更为突出。总之，真实的运动的基本激活和失活模式与想象运动的基本激活和失活模式相对应。差异可能是由于不同的运动模式测试。与[F-18]-FDG-PET中的恒定速度真实的运动（10分钟）相反，在重复的20秒周期内运动的心理意象包括步态启动和速度变化。真实的稳态运动似乎使用通过初级运动皮质的直接途径，而想象的调节运动是通过辅助运动皮质和基底神经节回路的间接途径。(C)2009 Elsevier Inc. All rights reserved.
The cortical, cerebellar and brainstem BOLD-signal changes have been identified with fMRI in humans during mental imagery of walking. In this study the whole brain activation and deactivation pattern during real locomotion was investigated by [F-18]FDG-PET and compared to BOLD-signal changes during imagined locomotion in the same subjects using fMRI. Sixteen healthy subjects were scanned at locomotion and rest with [F-18]-FDG-PET. In the locomotion paradigm subjects walked at constant velocity for 10 min. Then [F-18]-FDG was injected intravenously while subjects continued walking for another 10 min. For comparison fMRI was performed in the same subjects during imagined walking. During real and imagined locomotion a basic locomotion network including activations in the frontal cortex, cerebellum, pontomesencephalic tegmentum, parahippocampal, fusiform and occipital gyri, and deactivations in the multisensory vestibular cortices (esp. superior temporal gyros, inferior parietal lobule) was shown. As a difference, the primary motor and somatosensory cortices were activated during real locomotion as distinct to the supplementary motor cortex and basal ganglia during imagined locomotion. Activations of the brainstem locomotor centers were more prominent in imagined locomotion. In conclusion, basic activation and deactivation patterns of real locomotion correspond to that of imagined locomotion. The differences may be due to distinct patterns of locomotion tested. Contrary to constant velocity real locomotion (10 min) in [F-18]-FDG-PET, mental imagery of locomotion over repeated 20-s periods includes gait initiation and velocity changes. Real steady-state locomotion seems to use a direct pathway via the primary motor cortex, whereas imagined modulatory locomotion an indirect pathway via a supplementary motor cortex and basal ganglia loop. (C) 2009 Elsevier Inc. All rights reserved.