HIV-1 and influenza antibodies: seeing antigens in new ways
HIV-1 and influenza antibodies: seeing antigens in new ways
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DOI：
10.1038/ni.1746
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发表时间：
2009-06-01
影响因子：
30.5
通讯作者：
Wilson, Ian A.
中科院分区：
文献类型：
--
作者：
Kwong, Peter D.;Wilson, Ian A.
通过对中和人类免疫缺陷病毒1型和甲型流感病毒的抗体的研究，已经确定了新的体液识别模式。了解这种抗体-抗原识别模式如何在复杂的体液逃避机制中发生，对于开发有效的疫苗具有重要意义。在这里，我们描述了首次在人类免疫缺陷病毒1型中观察到的八种抗体识别模式。其中四种模式的相似性已被甲型流感病毒保守的“茎”表位的抗体所识别。我们概述了这些不同的抗体识别模式中的每一种如何特别适合于克服特定的病毒逃避策略，并评估了疫苗环境中重新激发的潜在途径。
New modes of humoral recognition have been identified by studies of antibodies that neutralize human immunodeficiency virus type 1 and influenza A viruses. Understanding how such modes of antibody-antigen recognition can occur in the context of sophisticated mechanisms of humoral evasion has implications for the development of effective vaccines. Here we describe eight modes of antibody recognition first observed with human immunodeficiency virus type 1. Similarities to four of these modes have been identified with antibodies to a conserved 'stem' epitope on influenza A viruses. We outline how each of these different modes of antibody recognition is particularly suited to overcoming a specific viral evasion tactic and assess potential routes of re-elicitation in vaccine settings.