Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii
Altered transcriptional activity of human endogenous retroviruses in neuroepithelial cells after infection with Toxoplasma gondii
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DOI：
10.1086/508496
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发表时间：
2006-11-15
影响因子：
6.4
通讯作者：
Seifarth, Wolfgang
中科院分区：
文献类型：
--
作者：
Frank, Oliver;Jones-Brando, Lorraine;Seifarth, Wolfgang
人类内源性逆转录病毒（herv）起源于古代，稳定地整合到人类基因组中。herv的激活机制尚未完全阐明。弓形虫病是由刚地弓形虫引起的一种医学上重要的寄生虫感染，分布在世界各地。为了寻找弓形虫病和HERV激活之间的初步联系，我们分析了感染弓形虫的人神经上皮细胞SK-N-MC的HERV表达谱。在感染细胞中观察到I、II和III类HERV元件的转录活性增加，这表明弓形虫可以影响神经元细胞中HERV的转录。
Human endogenous retroviruses ( HERVs) arose in antiquity from stable integration into the human genome. The mechanism for activation of HERVs has not been fully elucidated. Toxoplasmosis, caused by Toxoplasma gondii, is a medically important parasitic infection with worldwide distribution. To search for a tentative link between toxoplasmosis and HERV activation, HERV expression profiles of human neuroepithelial SK-N-MC cells infected with T. gondii were analyzed. Increased transcriptional activity of class I, II, and III HERV elements was observed in infected cells, suggesting that T. gondii can influence the transcription of HERVs in neuronal cells.