HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3
HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3
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DOI：
10.1006/bbrc.2000.3870
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发表时间：
2000-11-30
影响因子：
3.1
通讯作者：
Shimizu, K
中科院分区：
文献类型：
--
作者：
Toyooka, S;Ouchida, M;Shimizu, K
一个编码一种新的蛋白质酪氨酸磷酸酶的人基因已经被分离出来。该磷酸酶在结构域结构上有其独特的特点：一个含有几个SH3结合基序的“锌-手”结构域，一个酪氨酸磷酸酶结构域，一个C-末端PEST基序，以及一个类似于酵母BRO1(一种与细胞凋亡相关的哺乳动物AIP1)和一种Rho结合蛋白Rhophlin的N-末端结构域。该基因位于染色体3p21.3，这一区域在许多类型的癌症中经常缺失，特别是在功能定义的狭窄区域内。该基因可能是其他人报道的大鼠PTP-TD14基因的人类同源基因，可以抑制H-ras介导的转化。我们在一个肺癌细胞系中发现了一个半合子错义突变。因此，磷酸酶基因可能是位于3p21.3的肿瘤抑制基因之一的候选基因。(C)2000年学术出版社。
A human cDNA encoding a novel protein tyrosine phosphatase has been isolated. The phosphatase has unique features in its domain structure: a "Zn-hand" domain containing several SH3-binding motifs, a tyrosine phosphatase domain, a C-terminal PEST motif, and an N-terminal domain similar to yeast BRO1, an apoptosis-related mammalian AIP1 and to a RHO-binding protein, Rhophilin. The gene is located at chromosome 3p21.3, an area frequently deleted in many types of cancer, especially within the functionally defined narrow region. The gene may be a human homolog of the rat PTP-TD14 gene reported by others, which can suppress H-ras-mediated transformation. We identified a hemizygous missense mutation in a lung cancer cell line. Thus, the phosphatase gene may be a candidate for one of the tumor suppressor genes located on 3P21.3. (C) 2000 Academic Press.