Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.
Analysis of lung tumor initiation and progression in transgenic mice for Cre-inducible overexpression of Cul4A gene.
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Cre 诱导的 Cul4A 基因过表达转基因小鼠肺肿瘤的发生和进展分析
DOI：
10.1111/1759-7714.12257
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发表时间：
2015-07
期刊：
影响因子：
2.9
通讯作者：
You L
中科院分区：
文献类型：
--
作者：
Wang Y;Xu Z;Mao JH;Hung MS;Hsieh D;Au A;Jablons DM;You L
肺癌是全世界发病率和死亡的主要原因。尽管现有的肺癌动物模型已经提供了丰富的信息，并进一步推动了我们对人类肺癌的理解，但它们仍然不能完全概括人类肺癌的复杂性。与其他癌症相比，肺癌的发病机制仍然非常难以捉摸，因为它具有侵袭性的生物学性质和相当大的异质性。Cul4A扩增与肿瘤侵袭性生长和不良预后有关。我们之前的研究表明Cul4A在体外具有致癌作用，但其在体内的致癌作用尚未得到研究。
Lung cancer is the leading cause of morbidity and death worldwide. Although the available lung cancer animal models have been informative and further propel our understanding of human lung cancer, they still do not fully recapitulate the complexities of human lung cancer. The pathogenesis of lung cancer remains highly elusive because of its aggressive biologic nature and considerable heterogeneity, compared to other cancers. The association of Cul4A amplification with aggressive tumor growth and poor prognosis has been suggested. Our previous study suggested that Cul4A is oncogenic in vitro, but its oncogenic role in vivo has not been studied.