Switchable Divergent Synthesis Using Photocatalysis
Switchable Divergent Synthesis Using Photocatalysis
复制标题
DOI：
10.1021/acscatal.1c05318
复制
发表时间：
2022-01-20
期刊：
影响因子：
12.9
通讯作者：
Murakami, Kei
中科院分区：
文献类型：
--
作者：
Sakakibara, Yota;Murakami, Kei
高度选择性和发散性的合成能够获得各种分子，不仅引起了有机化学家的广泛兴趣，而且还引起了与化学图书馆合作的药物化学家和生物学家的广泛兴趣。自20世纪以来，这种不同的转化是通过过渡金属催化反应实现的，其中催化剂或配体的选择对选择性产生至关重要的影响。在过去的几十年里，光催化剂引起了相当多的关注，因为它们提供了通过电子或能量转移来控制反应中间体和产物选择性的额外方法。从这个角度来看，我们重点介绍了最近使用光催化剂进行可切换和发散合成的发展，这是使用经典催化转化难以实现的。
A highly selective and divergent synthesis enables access to various molecules and has garnered broad interest from not only organic chemists but also medicinal chemists and biologists who work with chemical libraries. Since the 20th century, such divergent transformations have been achieved using transition-metal-catalyzed reactions, in which the choice of catalyst or ligand crucially affects the selectivity. Over the past several decades, photocatalysts have attracted a considerable amount of attention because they provide additional ways to control the reaction intermediates and product selectivity via electron or energy transfer. From this perspective, we highlight the recent development of switchable and divergent syntheses using photocatalysts, which are difficult to achieve using classical catalytic transformations.