Differential gating of thalamocortical signals by reticular nucleus of thalamus during locomotion.
Differential gating of thalamocortical signals by reticular nucleus of thalamus during locomotion.
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DOI：
10.1523/jneurosci.0782-12.2012
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发表时间：
2012-11-07
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影响因子：
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通讯作者：
Beloozerova IN
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文献类型：
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作者：
Marlinski V;Sirota MG;Beloozerova IN
丘脑网状核（RE）对背侧丘脑提供抑制，并形成丘脑-皮质和皮质-丘脑信号之间的重要界面。尽管人们对RE在组织丘脑-皮质信号传导中的作用有很大的兴趣，但关于RE在清醒动物中的活动的信息却很少。在这里，我们研究了在清醒的，不受约束的猫在一个平面上的简单运动和复杂的运动沿着一个水平的梯子，需要视觉控制的步进的“电机”车厢内的神经元的活动。在运动过程中，该区域88%的神经元的活动受到调制。感受野的肩膀上的神经元位于背侧的核，并定期放电，在运动过程中，他们有相对较低的活动和适度幅度的步幅相关的调制，他们的组活动分布在步幅。相比之下，神经元的感受野的手腕/爪子位于更腹侧，经常放电的睡眠型爆发在运动过程中，非常活跃和深刻的调制，他们的群体活动集中在摆动和结束的立场。75%的RE神经元在两种运动任务中有不同的活动。我们的结论是，在运动的RE差异门丘脑皮层信号传输过程中的不同阶段的步幅，在肢体的不同部位，和运动任务的类型。
The thalamic reticular nucleus (RE) provides inhibition to the dorsal thalamus, and forms a crucial interface between thalamo-cortical and cortico-thalamic signals. Whereas there has been significant interest in the role of the RE in organizing thalamo-cortical signaling, information on the activity of the RE in the awake animal is scant. Here we investigated the activity of neurons within the ‘motor’ compartment of the RE in the awake, unrestrained cat during simple locomotion on a flat surface and complex locomotion along a horizontal ladder that required visual control of stepping. The activity of 88% of neurons in this region was modulated during locomotion. Neurons with receptive fields on the shoulder were located dorsally in the nucleus and had regular discharges; during locomotion they had relatively low activity and modest magnitudes of stride-related modulation, and their group activity was distributed over the stride. In contrast, neurons with receptive fields on the wrist/paw were located more ventrally, often discharged sleep-type bursts during locomotion, were very active and profoundly modulated, and their group activity was concentrated in the swing and end of stance. 75% of RE neurons had different activity during the two locomotion tasks. We conclude that during locomotion the RE differentially gates thalamo-cortical signals transmitted during different phases of the stride, in relation to different parts of the limb, and the type of locomotion task.