Overanxious and underslept
Overanxious and underslept
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DOI：
10.1038/s41562-019-0754-8
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发表时间：
2020-01-01
影响因子：
29.9
通讯作者：
Walker, Matthew P.
中科院分区：
文献类型：
--
作者：
Ben Simon, Eti;Rossi, Aubrey;Walker, Matthew P.
所有焦虑症的特征都是睡眠中断。Ben Simon等人建立了一个睡眠缺失引起焦虑的神经框架，强调非快速眼动睡眠是缓解焦虑的治疗目标。你感到焦虑吗？你昨晚睡得不好吗？睡眠中断是所有焦虑症的公认特征。在这里，我们研究了睡眠不足对焦虑影响的基本大脑机制。此外，我们还探讨了细微的、社会上普遍的睡眠减少是否会引发第二天焦虑的加剧。最后，我们从生理上考察了睡眠为何能在一夜之间减轻焦虑。我们证明，睡眠缺失的焦虑影响与内侧前额叶皮层活动受损以及与扩展边缘区域相关的连通性有关。相比之下，非快速眼动（NREM）慢波振荡在睡眠后对这些大脑网络有改善、抗焦虑的作用。与社会相关的是，我们确定，即使是每晚睡眠时间的适度减少，也会导致焦虑情绪每天都在增加。这些发现有助于解释睡眠和焦虑之间的密切联系，并进一步强调非快速眼动睡眠作为有意义地减少焦虑的治疗靶点的前景。
All anxiety disorders are characterized by sleep disruption. Ben Simon et al. develop a neural framework of sleep-loss-induced anxiety, one that emphasizes NREM sleep as a therapeutic target for anxiety amelioration.Are you feeling anxious? Did you sleep poorly last night? Sleep disruption is a recognized feature of all anxiety disorders. Here, we investigate the basic brain mechanisms underlying the anxiogenic impact of sleep loss. Additionally, we explore whether subtle, societally common reductions in sleep trigger elevated next-day anxiety. Finally, we examine what it is about sleep, physiologically, that provides such an overnight anxiety-reduction benefit. We demonstrate that the anxiogenic impact of sleep loss is linked to impaired medial prefrontal cortex activity and associated connectivity with extended limbic regions. In contrast, non-rapid eye movement (NREM) slow-wave oscillations offer an ameliorating, anxiolytic benefit on these brain networks following sleep. Of societal relevance, we establish that even modest night-to-night reductions in sleep across the population predict consequential day-to-day increases in anxiety. These findings help contribute to an emerging framework explaining the intimate link between sleep and anxiety and further highlight the prospect of non-rapid eye movement sleep as a therapeutic target for meaningfully reducing anxiety.