A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families.
A common founder for the V126D CDKN2A mutation in seven North American melanoma-prone families.
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V126D CDKN2A突变的共同创始人在七个北美黑色素瘤家庭中。
DOI：
10.1054/bjoc.2001.1944
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发表时间：
2001-08-17
影响因子：
8.8
通讯作者：
Struewing, J P
中科院分区：
文献类型：
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作者：
Goldstein, A M;Liu, L;Shennan, M G;Hogg, D;Tucker, M A;Struewing, J P
在北美报道的最常见的与黑色素瘤相关的CDKN2A突变之一是V126D突变。我们在携带V126D突变的三个美国和四个加拿大家庭中检测了CDKN2A周围的9个标记。所有7个家族的单倍型都与该突变的共同祖先/创始人一致。此外，该突变似乎起源于34-52代以前（1 lod单位支持间隔13-98代）。©2001癌症研究运动http:///www.bjcancer.com
One of the most common melanoma-related CDKN2A mutations reported in North America is the V126D mutation. We examined nine markers surrounding CDKN2A in three American and four Canadian families carrying the V126D mutation. All seven families had a haplotype consistent with a common ancestor/founder for this mutation. In addition, the mutation appears to have originated 34–52 generations ago (1-LOD-unit support interval 13–98 generations). © 2001 Cancer Research Campaign http:///www.bjcancer.com