Neuregulin-1 and the P300 waveform - A preliminary association study using a psychosis endophenotype
Neuregulin-1 and the P300 waveform - A preliminary association study using a psychosis endophenotype
复制标题
DOI：
10.1016/j.schres.2008.03.025
复制
发表时间：
2008-08-01
影响因子：
4.5
通讯作者：
Murray, Robin
中科院分区：
文献类型：
--
作者：
Bramon, Elvira;Dempster, Emma;Murray, Robin
目的：神经调节蛋白-1(NRG1)被认为是精神分裂症的易感基因。研究神经调节蛋白-1与精神分裂症内表型P300波的相关性。方法：研究对象为的精神分裂症或分裂情感性障碍患者、97名非精神病患者亲属和35名非亲属对照。当受试者进行双音辨别任务时，从脑电中提取P300波。结果：NeuRegin-1SNP8NRG221533单核苷酸多态和两个微卫星(4781314-848和420M9-1395)对P300波幅和潜伏期有显著影响，携带的C等位基因数目越多，潜伏期延迟越大。=32.4ms；95%可信区间：13.2ms~51.6ms；p=0.001]。P300潜伏期与NRG1微卫星和波幅之间无相关性。结论：P300潜伏期反映了神经传递的速度。我们假设，NRG1的变异可能通过扰乱神经连接，可能是白质完整性，导致认知处理速度减慢，从而传递精神分裂症的风险。这是在小样本中的初步发现，需要复制。(C)2008爱思唯尔B.V.保留所有权利。
Objective: Neuregulin-1 (NRG1) has been put for-ward as a susceptibility gene for schizophrenia. We investigated the association between Neuregulin-1 and the P300 wave, a schizophrenia endophenotype.Methods: Participants were 64 patients with DSM-IV schizophrenia or schizoaffective disorder, 97 of their non psychotic relatives and 35 unrelated controls. The P300 wave was extracted from the electroencephalogram whilst the subjects conducted a two-tone discrimination task. The effect of three markers from the core NRG-1 at-risk haplotype including single nucleotide polymorphism SNP8NRG221533 and two microsatellites (4781314-848 and 420M9-1395) on P300 amplitude and latency was examined using multilevel modelling.Results: Neuregulin-1 SNP8NRG221533 had a significant influence on P300 latency and the higher the number of C alleles carried, the greater the latency delay [Coef. = 32.4 ms; 95%CI: 13.2 to 51.6 ms; p = 0.001]. There was no association between latency and NRG1 microsatellites or between amplitude and any of the three markers examined.Conclusions: The P300 latency reflects the speed of neural transmission. We hypothesise that variation in NRG1 may convey risk for schizophrenia by disrupting neural connectivity, possibly white matter integrity, and leading to a slower speed of cognitive processing. This is a preliminary finding in a small sample and requires replication. (C) 2008 Elsevier B.V. All rights reserved.