ABO blood grouping in Egyptian children with rotavirus gastroenteritis
ABO blood grouping in Egyptian children with rotavirus gastroenteritis
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DOI：
10.5114/pg.2017.70469
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发表时间：
2017-01-01
影响因子：
1.3
通讯作者：
El-Taweel, Ahmed N.
中科院分区：
文献类型：
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作者：
Elnady, Hala Gouda;Samie, Ola M. Abdel;El-Taweel, Ahmed N.
前言：轮状病毒胃肠炎是世界范围内一个重要的公共卫生问题，在发展中国家和发达国家都造成了显著的经济负担。目的：探讨埃及儿童轮状病毒胃肠炎的血型、轮状病毒胃肠炎与其严重程度的关系。材料和方法：对Al-Zahraa大学医院门诊就诊的231例急性胃肠炎患者进行横断面病例对照研究。进行了完整的病史记录、临床检查和临床资料收集。采集血液样本进行ABO分型。对粪便标本进行病毒性胃肠炎病原体检测。结果：RotA阳性病例在A型血患者中显著高于B型血患者(p<；0.05)，而在B型血患者中显著较低(p<；0.05)。A组患者的住院率显著高于A组患者(p<；0.005)，AB组和O组患者的住院率显著低于A组患者(p<；0.05)。至于脱水的程度，A组和O组的中度和重度病例非常显著(p<；0.005)。轮状病毒阳性胃肠炎与严重程度指标如住院时间、脱水程度、发热时间呈显著正相关(p<；0.005)。结论：A型血型与小儿轮状病毒胃肠炎密切相关。这可能突出了一个重要的危险因素，它可能在轮状病毒胃肠炎的发病机制和严重程度中发挥重要作用。此外，对于A型血的儿科患者，如果胃肠炎，特别是轮状病毒感染，可能需要更多的干预护理，以避免合并疾病。
Introduction: Rotavirus gastroenteritis is an important public health problem all over the world, causing a notable economic burden in both developing and developed countries.Aim: To explore the relationship between blood group typing, rotavirus gastroenteritis, and its severity in Egyptian children.Material and methods: A cross sectional case control study was conducted on 231 cases of acute gastroenteritis attending the outpatient clinic of Al-Zahraa University Hospital. Full history taking, clinical examination, and clinical data collection were done. Blood samples were collected for an ABO grouping. Stool samples were tested for viral gastroenteritis agents.Results: Rota positive cases of GE were significantly more prevalent among cases with blood group A (p < 0.05) and significantly less among cases with blood group B (p < 0.05). The rate of hospitalisation was highly significantly greater among cases with group A (p < 0.005), and significantly lower among cases with group AB and O (p < 0.05). As regards the degree of dehydration, moderate and severe cases were highly significant in groups A and O (p < 0.005). Rota-positive gastroenteritis showed significant positive correlations with indicators of severity such as hospitalisation, degree of dehydration, and duration of fever (p < 0.005).Conclusions: Blood group A is highly associated with paediatric rotavirus gastroenteritis. This could highlight an important risk factor, which could play a significant role for the pathogenesis of rotavirus gastroenteritis and severity as well. Furthermore, more intervention care could be needed for blood group A paediatric patients, if gastroenteritis especially rotavirus affect this group to avoid comorbidities.