A novel combined method of thin-film evaporation and a supercritical carbon dioxide technique to prepare a fluorescent siRNA-liposome
A novel combined method of thin-film evaporation and a supercritical carbon dioxide technique to prepare a fluorescent siRNA-liposome
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DOI：
10.1039/c6ra19751e
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发表时间：
2016-09
期刊：
影响因子：
3.9
通讯作者：
Lielie Li;X. An
中科院分区：
文献类型：
--
作者：
Lielie Li;X. An
采用薄膜蒸发与超临界二氧化碳技术相结合的方法制备了新型叶酸- dtx / sirna脂质体（FDSL）。FDSLs不仅稳定性好、溶剂残留少、包封效率高、荧光示踪能力强，而且在Bcap-37乳腺癌细胞中具有明显的选择性蓄积。
A novel folate-DTX/siRNA-liposome (FDSL) was prepared by a combined method of thin-film evaporation and supercritical carbon dioxide technique. The FDSLs not only have good stability, lower solvent residue, high encapsulation efficiency and fluorescent tracing ability, but also possess distinct selectivity to accumulate in Bcap-37 breast cancer cells.