Anaplastic large-cell non-Hodgkin's lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer - a case report
Anaplastic large-cell non-Hodgkin's lymphoma of the breast in periprosthetic localisation 32 years after treatment for primary breast cancer - a case report
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DOI：
10.1007/s00428-006-0287-1
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发表时间：
2006-11-01
期刊：
影响因子：
3.5
通讯作者：
Kristiansen, Glen
中科院分区：
文献类型：
--
作者：
Fritzsche, Florian Rudolf;Pahl, Stefan;Kristiansen, Glen
原发性和继发性乳房淋巴瘤都是罕见疾病，在某些情况下，常规苏木精/伊红染色可能会被误诊为乳腺癌。我们报道了一名 72 岁女性患有间变性大细胞淋巴瘤的病例，她有乳腺癌病史，32 年前曾接受乳房消融手术和随后的硅植入手术。临床上，她出现了几个月内出现的皮肤溃疡。在传统的组织学上，肿瘤细胞模仿低分化的浸润性导管癌，具有显着的白细胞浸润。肿瘤的免疫特征显示细胞角蛋白呈阴性，并导致 CD30 阳性间变性大细胞淋巴瘤的诊断。
Primary, as well as secondary, lymphomas of the breast are rare diseases and might, in some cases, be misdiagnosed as breast cancer on routine hematoxylin/eosin stainings. We report a case of an anaplastic large cell lymphoma in a 72-year-old woman with a history of breast cancer treated with breast-ablative surgery and a subsequent silicon implant 32 years ago. Clinically, she presented with an ulceration of the skin, which had developed within a few months. On conventional histology, the tumor cells were mimicking poorly differentiated invasive ductal carcinoma with a prominent leukocytic infiltrate. The immunoprofile of the tumor showed negativity for cytokeratins and led to the diagnosis of a CD30-positive anaplastic large cell lymphoma.