Recent Progress in 808 nm Excited Upconversion Nanomaterials as Multifunctional Nanoprobes for Visualized Theranostics in Cancers.
Recent Progress in 808 nm Excited Upconversion Nanomaterials as Multifunctional Nanoprobes for Visualized Theranostics in Cancers.
复制标题
808 nm 激发上转换纳米材料作为多功能纳米探针用于癌症可视化治疗诊断的最新进展。
DOI：
10.2174/0929867324666170320115959
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发表时间：
2017-03
影响因子：
4.1
通讯作者：
Lu Guangming
中科院分区：
文献类型：
--
作者：
Zeng Leyong;Wu Di;Tian Ying;Pan Yuanwei;Wu Aiguo;Zhang Jinchao;Lu Guangming
近红外（NIR）光响应纳米材料由于其在生物窗口中的位置而引起了相当大的关注。特别是镧系元素掺杂的纳米材料表现出独特的上转换发光（UCL）特性，具有低背景干扰和长发光寿命等特点，在肿瘤的影像诊断中具有广阔的应用前景。与传统的980 nm激光激发的上转换纳米材料相比，808 nm激发可以克服激发源诱导的高加热效应和弱穿透深度的缺点。因此，开发808 nm激发的上转换纳米探针对于体内生物成像和深部组织中肿瘤的可视化治疗诊断将是重要的。本文系统总结了Nd3+敏化上转换纳米材料的合成策略及其在808 nm激发下的发光调制，讨论了激发源对加热效应和穿透深度的影响，重点介绍了其在UCL成像、多模态成像和肿瘤成像引导治疗中的应用。
Near-infrared (NIR) light responsive nanomaterials have attracted considerable attention due to their location in the biological window. Especially, lanthanide-doped nanomaterials exhibit unique upconversion luminescence (UCL) properties with low background interference and long luminescence lifetime, which makes them promising in imaging diagnosis of cancers. Compared with traditional upconversion nanomaterials excited by 980 nm laser, 808 nm excitation can overcome the disadvantages of high heating effect and weak penetration depth induced by excitation source. Therefore, developing 808 nm excited upconversion nanoprobes will be important for the in vivo bio-imaging and visualized theranostics of tumors in deep-tissue. In the review paper, we systematically summarized the synthesis strategy and luminescence modulation of Nd3+-sensitized upconversion nanomaterials under 808 nm excitation, discussed the influence of excitation source on heating effect and penetration depth, and particularly focused on their applications in UCL imaging, multi-modal imaging and imaging-guided therapy of cancers.