PROLONGED STIMULATION OF RESPIRATION BY ENDOGENOUS CENTRAL SEROTONIN
PROLONGED STIMULATION OF RESPIRATION BY ENDOGENOUS CENTRAL SEROTONIN
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DOI：
10.1016/0034-5687(80)90113-9
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
WALDROP, TG
中科院分区：
文献类型：
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作者：
MILLHORN, DE;ELDRIDGE, FL;WALDROP, TG
有一种神经脑干机制，通过刺激颈动脉小体传入大脑而独特地激活，并在刺激的即时影响消散后促进几个小时的呼吸。在迷走神经切断、麻醉和瘫痪的猫，其呼气末二氧化碳分压[CO2分压]和温度被伺服控制并保持恒定，测定了对颈动脉体神经或颈动脉窦神经刺激的呼吸反应。对用不同的5-羟色胺拮抗剂和一种多巴胺-去甲肾上腺素拮抗剂处理的动物的反应与未处理的对照动物的反应进行比较。所有3种不同作用的5-羟色胺拮抗剂(甲基丝氨酸、对氯苯丙氨酸和5，7-二羟色胺)均可预防或显著降低长期呼吸反应的幅度；多巴胺-去甲肾上腺素拮抗剂(α-甲基酪氨酸)不能改变这种反应。刺激颈动脉小体传入后呼吸活动的持续增加是由于激活了促进呼吸的内源性中枢5-羟色胺能机制。
There is a neural brainstem mechanism which is uniquely activated by stimulation of carotid body afferent input to the brain and which facilitates respiration for hours after the immediate affects of the stimulation dissipated. Respiratory responses to carotid body or carotid sinus nerve stimulation were measured in vagotomized, anesthetized and paralyzed cats whose end-tidal PCO2 [CO2 partial pressure] and temperature were servo-controlled and kept constant. The responses of animals pretreated with various serotonin antagonists and a dopamine-norepinephrine antagonist were compared to the responses of untreated control animals. All 3 different acting serotonin antagonists (methysergide, parachlorophenylalanine and 5,7-dihydroxytryptamine) prevented or significantly reduced the magnitude of the long-lasting respiratory response; the dopamine-norepinephrine antagonist (.alpha.-methyltyrosine) did not alter it. The long-lasting increase of respiratory activity following stimulation of carotid body afferents is due to activation of an endogenous central serotoninergic mechanism which facilitates respiration.