Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus.
Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus.
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DOI：
10.3389/fendo.2012.00180
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发表时间：
2012
影响因子：
5.2
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Chen P;Hover CV;Lindberg D;Li C
促肾上腺皮质激素释放因子（CRF）肽家族在大脑中协调应激反应的重要作用已被广泛记录。CRF的作用由两种G蛋白偶联受体介导，即1型和2型CRF受体（CRF 1和CRF 2）。虽然CRF 1在激素和行为适应压力中的功能作用是众所周知的，但CRF 2的生理意义仍有待充分认识。越来越多的证据表明，CRF 2及其选择性配体包括尿皮质素3（Ucn 3）是调节能量平衡的重要分子介质。Ucn 3是CRF肽家族的最新成员，对CRF 2具有高度选择性。最近的研究表明，中央Ucn 3是重要的，在许多稳态功能，包括抑制进食，血糖水平的调节，和体温调节，从而加强中央CRF 2在代谢调节中的功能作用。介导Ucn 3中枢效应的脑位点仍有待完全确定。解剖学和功能证据表明，腹内侧下丘脑（VMH），其中CRF 2的显着表达，似乎是在介导的Ucn 3对能量平衡的影响，允许Ucn 3介导的喂养和血糖控制的调制工具。因此，Ucn 3-VMH CRF 2系统是调节能量稳态的重要神经通路，并且在响应代谢扰动和应激以维持能量平衡的能量适应中潜在地起关键作用。
The vital role of the corticotropin-releasing factor (CRF) peptide family in the brain in coordinating response to stress has been extensively documented. The effects of CRF are mediated by two G-protein-coupled receptors, type 1 and type 2 CRF receptors (CRF1 and CRF2). While the functional role of CRF1 in hormonal and behavioral adaptation to stress is well-known, the physiological significance of CRF2 remains to be fully appreciated. Accumulating evidence has indicated that CRF2 and its selective ligands including urocortin 3 (Ucn 3) are important molecular mediators in regulating energy balance. Ucn 3 is the latest addition of the CRF family of peptides and is highly selective for CRF2. Recent studies have shown that central Ucn 3 is important in a number of homeostatic functions including suppression of feeding, regulation of blood glucose levels, and thermoregulation, thus reinforcing the functional role of central CRF2 in metabolic regulation. The brain loci that mediate the central effects of Ucn 3 remain to be fully determined. Anatomical and functional evidence has suggested that the ventromedial hypothalamus (VMH), where CRF2 is prominently expressed, appears to be instrumental in mediating the effects of Ucn 3 on energy balance, permitting Ucn 3-mediated modulation of feeding and glycemic control. Thus, the Ucn 3-VMH CRF2 system is an important neural pathway in the regulation of energy homeostasis and potentially plays a critical role in energy adaptation in response to metabolic perturbations and stress to maintain energy balance.