Coherent amygdalocortical theta promotes fear memory consolidation during paradoxical sleep
Coherent amygdalocortical theta promotes fear memory consolidation during paradoxical sleep
复制标题
DOI：
10.1073/pnas.0913016107
复制
发表时间：
2010-04-06
影响因子：
11.1
通讯作者：
Pare, Denis
中科院分区：
文献类型：
--
作者：
Popa, Daniela;Duvarci, Sevil;Pare, Denis
睡眠中的大脑活动在记忆巩固中起着至关重要的作用，这是一个离线过程，决定了记忆痕迹的长期强度。巩固疗效因个体而异，但这些差异背后的大脑活动动力学仍然未知。在这里，我们研究了恐惧记忆巩固的个体间差异与参与巴甫洛夫恐惧学习的大脑结构中的神经活动的关系。从训练结束到24 h后测试，部分大鼠出现条件性恐惧反应增强，部分大鼠出现条件性恐惧反应减弱。我们发现，夜间恐惧记忆的双向变化选择性地与modi相关。异相睡眠中杏仁核、内侧前额叶皮层和海马体之间θ波相干性的阳离子。因此，我们的研究结果表明，在边缘系统的θ协调可能会影响个体间的差异，记忆巩固的厌恶的经验。
Brain activity in sleep plays a crucial role in memory consolidation, an offline process that determines the long-term strength of memory traces. Consolidation efficacy differs across individuals, but the brain activity dynamics underlying these differences remain unknown. Here, we studied how interindividual variability in fear memory consolidation relates to neural activity in brain structures that participate in Pavlovian fear learning. From the end of training to testing 24 h later, some rats showed increased and others decreased conditioned fear responses. We found that overnight bidirectional changes in fear memory were selectively correlated with modi. cations in theta coherence between the amygdala, medial prefrontal cortex, and hippocampus during paradoxical sleep. Thus, our results suggest that theta coordination in the limbic system may influence interindividual differences in memory consolidation of aversive experiences.