Leptin reverses declines in satiation in weight-reduced obese humans
Leptin reverses declines in satiation in weight-reduced obese humans
复制标题
DOI：
10.3945/ajcn.111.012385
复制
发表时间：
2012-02-01
影响因子：
7.1
通讯作者：
Rosenbaum, Michael
中科院分区：
文献类型：
--
作者：
Kissileff, Harry R.;Thornton, John C.;Rosenbaum, Michael
背景资料：与从未减肥的对照组相比，体重减轻或瘦素缺乏的个体具有较低的能量消耗，以及较高的饥饿感和抑制解除和/或延迟饱腹感。由于外源性瘦素抑制先天性瘦素缺乏的人的摄食，因此瘦素信号的减少可能会降低人类摄食抑制的表达。目的：验证瘦素信号减少可能会降低摄食抑制的表达的假设通过检查瘦素补充对减肥后进食行为的影响，在人类中（即，钝饱）。设计：研究对象为10名肥胖患者（4男6女），他们接受了维持体重的液体配方饮食。通过测量摄入量和摄入300千卡液体配方饮食后3小时的食欲相关处置的评级来研究饱腹感。在3个时间段中的每一个时间段对受试者进行研究：（1）保持正常体重（体重（初始）），然后在体重减轻和稳定在低于初始体重10%后，同时接受5周的2）每日两次安慰剂注射（Wt（-10%安慰剂））或（3）“替代剂量”瘦素（Wt（-10%瘦素）），采用单盲交叉设计，两种治疗之间有2周的洗脱期。结果：体重减轻（-10%placebo）组的能量消耗和反映饱食的视觉模拟量表评分均显著低于体重减轻（初始）组和体重减轻（-10%leptin）组。结论：体重减轻后瘦素信号的缺失可能会减弱人类摄食抑制的表达。美国临床营养杂志2012;95：309-17。
Background: Individuals who are weight-reduced or leptin deficient have a lower energy expenditure coupled with higher hunger and disinhibition and/or delayed satiation compared with never-weight-reduced control subjects. Because exogenous leptin inhibits feeding in congenitally leptin-deficient humans, reduced leptin signaling may reduce the expression of feeding inhibition in humans.Objective: The objective was to test the hypothesis that reduced leptin signaling may reduce the expression of feeding inhibition (ie, blunt satiation) in humans by examining the effects of leptin repletion on feeding behavior after weight loss.Design: Ten obese humans (4 men, 6 women) were studied as inpatients while they received a weight-maintaining liquid-formula diet. Satiation was studied by measuring intake and ratings of appetite-related dispositions 3 h after ingestion of 300 kcal of the liquid-formula diet. The subjects were studied at each of 3 time periods: /) while they maintained their usual weight (Wt(initial)) and then after weight reduction and stabilization at 10% below initial weight and while they received 5 wk of either 2) twice-daily injections of placebo (Wt(-10%placebo)) or 3) "replacement doses" of leptin (Wt(-10%leptin)) in a single-blind crossover design with a 2-wk washout period between treatments. Energy expenditure was also measured at each study period.Results: Both energy expenditure and visual analog scale ratings that reflect satiation were significantly lower at Wt(-10%placebo) than at Wt(initial) and Wt(-10%leptin).Conclusion: The results are consistent with the hypothesis that the absence of leptin signaling after weight loss may blunt the expression of feeding inhibition in humans. Am J Clin Nutr 2012;95:309-17.