Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation.
Acute regulation of tyrosine hydroxylase by nerve activity and by neurotransmitters via phosphorylation.
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DOI：
10.1146/annurev.ne.12.030189.002215
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发表时间：
1989
影响因子：
13.9
通讯作者：
R. Zigmond;M. Schwarzschild;A. Rittenhouse
中科院分区：
文献类型：
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作者：
R. Zigmond;M. Schwarzschild;A. Rittenhouse
虽然肾上腺素能神经或肾上腺嗜铬细胞的刺激导致释放的儿茶酚胺，在许多情况下，它不会导致这些细胞的儿茶酚胺含量的减少。T. R. Elliot（1 9 1 2）在一项研究中，旨在确定肾上腺髓质释放的儿茶酚胺是否受内脏神经控制。虽然Elliot获得了支持这一观点的大量数据，但他也发现，内脏神经的长时间电刺激并没有导致肾上腺儿茶酚胺含量的明显减少。事实上，埃利奥特写道：“内脏神经感应电刺激引起的肾上腺素残留变化是如此之小，以至于它永远不足以让我相信内脏控制的存在。Holland & Schumann（1956）后来通过直接测量内脏神经刺激过程中释放的儿茶酚胺的量以及刺激前后肾上腺中儿茶酚胺的含量来扩展这些发现。他们观察到，进入血液的儿茶酚胺的输出
Although stimulation of adrenergic nerves or adrenal chromaffin cells causes the release of catecholamines, in many cases it does not cause a decrease in the catecholamine content of these cells. One of the first reports of this phenomenon was made by T. R. Elliot ( 1 9 1 2) in a study designed to establish whether the release of catecholamines by the adrenal medulla was controlled by the splanchnic nerves. Although Elliot obtained con siderable data supporting this view, he also found that prolonged electrical stimulation of the splanchnic nerves did not produce a pronounced depletion of the content of adrenal catecholamines. In fact, Elliot wrote, "so slight is the change in the residual adrenalin caused by faradisation of the splanchnic nerves, that it would never have sufficed to convince me of the existence of the splanchnic control." Holland & Schumann ( 1956) later extended these findings by measuring directly the amount of catechol amines released during splanchnic nerve stimulation and the content of catecholamines in the adrenal gland before and after the stimulation. They observed that the output of catecholamines into the blood stream