Helicobacter pylori infection induced genome instability and gastric cancer
Helicobacter pylori infection induced genome instability and gastric cancer
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DOI：
10.1007/s42764-020-00010-1
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发表时间：
2020-04
期刊：
影响因子：
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通讯作者：
Xiangyu Liu;M. Irfan;Xingzhi Xu;C. Tay;B. Marshall
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文献类型：
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作者：
Xiangyu Liu;M. Irfan;Xingzhi Xu;C. Tay;B. Marshall
基因组的稳定性和完整性不断受到细菌感染等外源损伤的挑战。当基因组稳定性受到干扰时，致癌转化就会随之而来。幽门螺杆菌(H。幽门螺杆菌感染是胃癌的驱动因素，胃癌是全球癌症相关死亡的第三大原因。从力学上看,H。幽门杆菌感染引发炎症，并直接或间接诱导宿主细胞的DNA损伤，如氧化损伤和双链断裂（DSBs）。此外，由此产生的遗传和/或表观遗传扰动改变了DNA修复途径的选择。这些变化导致不精确的DNA修复，基因组不稳定以及染色体畸变，最终导致胃癌的发生。在这篇综述中，我们总结了h。幽门杆菌感染引起DNA损伤并改变宿主细胞的DNA损伤反应途径。我们强调h。幽门感染和基因组不稳定性可导致胃癌，并提出一种潜在的策略来中断胃癌的发生。
Genome stability and integrity are constantly challenged by exogenous insults such as bacterial infections. When genome stability is perturbed, oncogenic transformation can ensue.Helicobacter pylori(H. pylori) infection is a driving factor of gastric cancer, which is the third leading cause of cancer-related mortality worldwide. Mechanistically,H. pyloriinfection drives inflammation and directly or indirectly induces DNA damage such as oxidative damage and double-strand breaks (DSBs) in host cells. In addition, the resulting genetic and/or epigenetic perturbations alter the choice of DNA repair pathways. These changes result in imprecise DNA repair, genomic instability as well as chromosomal aberrations that eventually lead to gastric carcinogenesis. In this review, we summarize the mechanisms howH. pyloriinfection cause DNA damage and alter the DNA damage response pathways in host cells. We highlight the relationship betweenH. pyloriinfection and genomic instability that can lead to gastric cancer and propose a potential strategy to interrupt gastric carcinogenesis.