THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY AND INTENSITY-MODULATED RADIATION THERAPY COMBINED WITH TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION FOR LOCALLY ADVANCED HEPATOCELLULAR CARCINOMA: AN IRRADIATION DOSE ESCALATION STUDY
THREE-DIMENSIONAL CONFORMAL RADIATION THERAPY AND INTENSITY-MODULATED RADIATION THERAPY COMBINED WITH TRANSCATHETER ARTERIAL CHEMOEMBOLIZATION FOR LOCALLY ADVANCED HEPATOCELLULAR CARCINOMA: AN IRRADIATION DOSE ESCALATION STUDY
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DOI：
10.1016/j.ijrobp.2009.10.070
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发表时间：
2011-02-01
影响因子：
7
通讯作者：
Jiang, Guo-Liang
中科院分区：
文献类型：
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作者：
Ren, Zhi-Gang;Zhao, Jian-Dong;Jiang, Guo-Liang
目的：探讨三维适形放疗(3DCRT)/调强放疗（IMRT）联合经导管动脉化疗栓塞治疗局部晚期肝癌的最大耐受剂量（MTD）。方法与材料：根据肿瘤直径将患者分为2个亚组：1组肿瘤= 10 cm；两组中每个队列的剂量均增加4.0 Gy。剂量限制性毒性（DLT）被定义为>= 3级急性肝脏或胃肠道毒性或任何5级急性其他器官毒性或辐射引起的肝脏疾病。当队列中8例患者中>= 2例发生DLT时，剂量递增将终止。结果：2005年4月至2008年5月，共纳入40例患者。在第一组，11例患者有分级
Purpose: To determine the maximum tolerated dose (MTD) of three-dimensional conformal radiation therapy (3DCRT)/intensity-modulated radiation therapy (IMRT) combined with transcatheter arterial chemoembolization for locally advanced hepatocellular carcinoma.Methods and Materials: Patients were assigned to two subgroups based on tumor diameter: Group 1 had tumors = 10 cm. Escalation was achieved by increments of 4.0 Gy for each cohort in both groups. Dose-limiting toxicity (DLT) was defined as a grade of >= 3 acute liver or gastrointestinal toxicity or any grade 5 acute toxicity in other organs at risk or radiation-induced liver disease. The dose escalation would be terminated when >= 2 of 8 patients in a cohort experienced DLT.Results: From April 2005 to May 2008,40 patients were enrolled. In Group I, 11 patients had grade