ETS1 polymorphism rs73013527 in relation to serum RANKL levels among patients with RA.
ETS1 polymorphism rs73013527 in relation to serum RANKL levels among patients with RA.
复制标题
ETS1多态性rs73013527与RA患者血清RANKL水平的关系
DOI：
10.1097/md.0000000000024562
复制
发表时间：
2021-02-05
期刊：
影响因子：
1.6
通讯作者：
Huang Z
中科院分区：
文献类型：
--
作者：
Yang B;Luo L;Chen L;Niu Q;Zhang J;Xu H;Wu Y;Huang Z
我们之前鉴定了与 RA 易感性和疾病活动相关的 E26 转化特异性序列 1 (ETS1) rs73013527 单核苷酸多态性。在本研究中，我们旨在进一步研究 ETS1 rs73013527 与核因子 kappa B 配体受体激活剂 (RANKL) 之间的关联，RANKL 是一个与骨质破坏相关的指数，据报道在 RA 中会升高。我们测定了 254 例 RA 病例的 ETS1 rs73013527 基因型、血清 RANKL 浓度、临床特征（疾病持续时间、28 个疼痛/肿胀关节的疾病活动评分）和实验室标志物（类风湿因子、抗瓜氨酸蛋白抗体、抗角蛋白抗体、C 反应蛋白、红细胞沉降率）。采用单变量和多变量分析探讨 RA 患者 ETS1 rs73013527 与血清 RANKL 水平之间的关联。单变量和多变量分析表明血清 RANKL 水平与患者年龄、性别、临床特征和实验室标志物没有关联。单变量分析而非多变量分析表明，ETS1 rs73013527 的基因型 CT/TT 与 RA 患者中 RANKL 水平升高显着相关。 ETS1 rs73013527 与 RA 患者的血清 RANKL 水平相关。 ETS1可能是参与RA RANKL调节的间接因素。
We previously identified E26 transformation specific sequence 1 (ETS1) rs73013527 single nucleotide polymorphism associated with RA susceptibility and disease activity. In the present study, we aims to further investigate the association between ETS1 rs73013527 and receptor activator of nuclear factor kappa B ligand (RANKL), an index related to bone destruction and was reported to elevate in RA. We determined genotypes of ETS1 rs73013527, serum RANKL concentration, clinical characteristics (disease duration, disease activity score for 28 painful/swollen joints), and laboratory markers (rheumatoid factor, anti-citrullinated protein antibody, anti-keratin antibody, c-reactive protein, erythrocyte sedimentation rate) of 254 RA cases. Univariate and multivariate analysis were employed to explore the association between ETS1 rs73013527 and serum RANKL levels in RA patients. Univariate and multivariate analysis indicated no association of serum RANKL levels with patient age, gender, clinical characteristics, and laboratory markers. Univariate analysis, not multivariate analysis indicated genotype CT/TT of ETS1 rs73013527 was significantly associated with elevated RANKL levels in RA patients. ETS1 rs73013527 is in relation to serum RANKL levels among patients with RA. ETS1 probably might be an indirect factors involved in RANKL regulation in RA.