Lymphangiogenesis and cancer.
Lymphangiogenesis and cancer.
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DOI：
10.1177/1947601911423028
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发表时间：
2011-12-01
期刊：
影响因子：
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通讯作者：
Detmar, Michael
中科院分区：
文献类型：
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作者：
Christiansen, Ailsa;Detmar, Michael
历史上，淋巴管被认为是肿瘤转移的被动参与者，只是为肿瘤细胞提供通道，以转移到引流淋巴结。然而，几种关键的淋巴管特异性分子标记物的发现以及用于研究淋巴生物学的体外和体内实验系统的增加的可用性突出了淋巴管系统在转移性肿瘤扩散中的更复杂的、积极的作用。本文将简要描述淋巴系统和淋巴管生成，然后重点介绍淋巴系统在癌症转移中的作用。我们的理解进展从淋巴系统作为一个有点被动的管道转移到转移性肿瘤传播的积极参与者，由淋巴管生成因子，趋化因子和免疫细胞亚群的复杂阵列调节，将被描述。
Historically, lymphatic vessels were considered passive participants in tumor metastasis by simply providing channels for tumor cells to transit to draining lymph nodes. The discovery of several key lymphatic-specific molecular markers and an increased availability of in vitro and in vivo experimental systems to study lymphatic biology have however highlighted a much more complex, active role for the lymphatic vasculature in metastatic tumor spread. This review will briefly describe the lymphatic system and lymphangiogenesis and then focus on the role of the lymphatic system in cancer metastasis. The progression of our understanding from the lymphatic system as a somewhat passive conduit for metastasis to an active participant in metastatic tumor dissemination, regulated by a complex array of lymphangiogenic factors, chemokines, and immune cell subsets, will be described.