Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
Diffuse optical measurement of blood flow, blood oxygenation, and metabolism in a human brain during sensorimotor cortex activation
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DOI：
10.1364/ol.29.001766
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发表时间：
2004-08-01
期刊：
影响因子：
3.6
通讯作者：
Yodh, AG
中科院分区：
文献类型：
--
作者：
Durduran, T;Yu, GQ;Yodh, AG
我们结合漫射光学和相关光谱来同时测量成人大脑在感觉运动刺激期间的氧合血红蛋白和脱氧血红蛋白浓度以及血流量。据我们所知，这些观察结果首次利用全光学方法计算人脑中氧的相对脑代谢率。由此证明了对成人大脑头骨血流进行无创光学测量的可行性，并且现在可以探索这种混合、全光学无创方法的临床潜力。 (C) 2004 年美国光学学会。
We combine diffuse optical and correlation spectroscopies to simultaneously measure the oxyhemoglobin and deoxyhemoglobin concentration and blood flow in an adult human brain during sensorimotor stimulation. The observations permit calculation of the relative cerebral metabolic rate of oxygen in the human brain, for the first time to our knowledge, by use of all-optical methods. The feasibility for noninvasive optical measurement of blood flow through the skull of an adult brain is thus demonstrated, and the clinical potential of this hybrid, all-optical noninvasive, methodology can now be explored. (C) 2004 Optical Society of America.